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LYMPHATIC METASTASIS OF MELANOMA TUMOR CELLS

LYMPHATIC METASTASIS OF MELANOMA TUMOR CELLS
黑色素瘤细胞的淋巴转移
批准号：
3088581
负责人：
DANIEL M RAMOS
金额：
$7.12万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1988
资助国家：
美国
项目状态：
已结题
起止时间：
1988-07-01 至 1993-06-30
来源：
https://reporter.nih.gov/project-details/3088581
关键词：
cell adhesion extracellular matrix head /neck neoplasm laboratory mouse lymph nodes melanoma membrane activity metastasis neoplastic cell physical chemical interaction training

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英文摘要
The interactions of tumor cells with the extracellular matrix found within the lymph nodes will be studied. Understanding how tumor cells invade the lymphatics and interact with the components of the extracellular matrix may explain why this tissue is such a fertile environment for tumor cell growth. This is especially relevant to head and neck cancers in which lymphatic metastasis is the primary mechanism of tumor dissemination. The specific aims are (1) to characterize the mouse B16 melanoma model for lymphatic metastasis; (2) to examine the adhesion of metastatic cells to lymph node tissue elements; (3) to examine the role of tumor cell surface adhesion receptors in extracellular matrix interactions.
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