MINORITY SCHOOL FACULTY DEVELOPMENT AWARD

突触前外周多巴胺受体（DA 2）的刺激产生 交感神经抑制导致低血压。 突触后外周 多巴胺受体（DA 1）激活亚组的血管舒张和利尿作用。 外周血高特异性受体激动剂的设计与合成 多巴胺受体已经发展成为一种新的控制方法， 高血压 N，N-二正丙基多巴胺对外周血淋巴细胞的作用 多巴胺受体导致血压降低和心脏收缩 这一速度刺激了类似化合物的合成。 的潜在 这些取代的（芳烷基）苯乙胺的临床应用是 当前感兴趣的话题。 本研究项目建议（a）合成和表征一系列 苯乙胺的N-芳烷基衍生物和相关化合物，（B） 评价这些化合物对外周多巴胺的有效性 受体利用局部血流测量（脉冲多普勒 流量计）和（c）进一步表征外周多巴胺 使用化学探针的受体（即，重金属）。 合成方案 发展将是这次调查的重点。 局部血 将在清醒和麻醉的动物中进行流量测量 外周多巴胺受体活性。 化学探测 受体也将使用局部血流测量技术。 的 这项研究很重要，因为它可以提供一系列新的 抗高血压药物和关于外周血管的其他信息 多巴胺受体

Stimulation of presynaptic peripheral dopamine receptors (DA2) produces sympathoinhibition resulting in hypotension. Postsynaptic peripheral dopamine receptor (DA1) activation subserver's vasodilation and diuresis. The design and synthesis of highly specific agonists for peripheral dopamine receptors have evolved into a new approach for the control of hypertension. The action of N, N-di-n-propyldopamine on peripheral dopamine receptors resulting in reduced blood pressure and reduced heart rate has stimulated the synthesis of similar compounds. The potential clinical application of these substituted (aralkyl) phenethylamines is a topic of current interest. This research project proposes to (a) synthesize and characterize a series of N-aralkyl derivatives of phenethylamine and related compounds, (b) evaluate the effectiveness of these compounds on peripheral dopamine receptors utilizing regional blood flow measurements (pulsed Doppler flowmeter) in rats and (c) further characterize the peripheral dopamine receptors using chemical probes (i.e., heavy metals). Synthetic scheme development will be a major thrust of this investigation. Regional blood flow measurements will be performed in conscious and anesthetized animals for peripheral dopamine receptor activity. Chemical probing of the receptors will also use the regional blood flow measurement technique. The proposed research is significant because it may provide new series of antihypertensive agents and additional information about peripheral dopamine receptors.