MOTOR & LIMBIC SYSTEM INTEGRATION IN SCHIZOPHRENIA

NIMH内科科学家奖的目的是获得作为 独立研究人员将探索颈椎病的神经解剖学基础 精神分裂症。基底节在调节中枢神经系统整合中的作用 不同的输入形成运动相关、联想相关和边缘相关的皮质和 基底神经节内的整合缺陷如何在 将对精神分裂症患者的复杂症状进行研究。这个 腹侧纹状体和苍白球可能代表基底的一部分。 运动和边缘相关通路整合的神经节，通过 由于它们与这两个功能区之间的联系。 奖学金计划的第一阶段部分(1-2年)涉及一般 神经解剖学、神经生理学和 神经内分泌学和有关神经科学一般主题的研讨会 和基底节功能。介绍性研究经验将是 通过与哈伯博士在持续和独立的实验室合作获得 以检测边缘和运动的整合为中心的实验- 基底节的相关通路。 培训方案的第二阶段(3-5年)包括 最初在啮齿动物身上进行的独立实验，旨在探索这种作用 腹侧苍白球的传出投射作为潜在的介体 边缘和运动的整合以及这种整合的机制 整合发生了。这些实验将探索这种差异 苍白球背侧(运动)和腹侧(边缘)的投射 黑质、丘脑底核和腹侧被盖区； 苍白球腹侧传出纤维的侧支投射 腹侧苍白球突出于边缘和非边缘区域。 顺行示踪剂(PHAL、滴定氨基酸、WGAS-HRP)和逆行示踪剂 示踪剂(荧光染料，WGA-HRP)与多肽和 酪氨酸羟化酶免疫细胞化学将在这些 实验。

The purpose of this NIMH Physician Scientist Award is to gain skills as an independent researcher to explore the neuroanatomic basis of schizophrenia. the role of the basal ganglia in mediating integration of diverse inputs form motor-, association-, and limbic-related cortices and how faulty integration within the basal ganglia may be manifest in the complex symptomatology of schizophrenic patients will be studied. The ventral striatum and globus pallidus, may represent portions of the basal ganglia where integration of motor- and limbic-related pathways occurs by virtue of their connections to both functional regions. The Phase I portion (years 1-2) of the fellowship program involves general graduate coursework in neuroanatomy, neurophysiology, and neuroendocrinology and seminars concerning general topics in neuroscience and basal ganglia function. Introductory research experience will be obtained by working with Dr. Haber on ongoing and independent laboratory experiments which center on examining the integration of limbic and motor- related pathways of the basal ganglia. The Phase II portion (years 3-5), of the training program involves independent experiments, initially in rodents, designed to explore the role of the efferent projections of the ventral pallidum as potential mediators of limbic and motor integration and the mechanisms by which this integration occurs. These experiments will explore the differential projections of dorsal (motor) and ventral (limbic) pallidum to the substantia nigra, subthalamus nucleus and ventral tegmental area; whether collateralization of ventral pallidal efferent fibers to cells in the ventral pallidum which project to limbic and non-limbic regions. Anterograde tracers (PHAL, titrated amino acids, WGAS-HRP) and retrograde tracers (fluorescent dyes, WGA-HRP) in combination with peptide and tyrosine hydroxylase immunocytochemistry will be utilized in these experiments.