Engineering approaches towards atomic imaging of bacterial cells

细菌细胞原子成像的工程方法

• 批准号: DP180103955
• 负责人: A/Prof Jing Fu
• 金额: $ 27.5万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180103955
• 关键词: Engineering; approaches; towards; atomic; imaging

This project aims to develop novel approaches for analysis of single biological cells at atomic scale. The project will first develop an approach by utilising nanoscale ion beam to interact with the frozen cells in a controllable manner, followed by performing nanoscale dissection and analyses. By introducing engineered two-dimensional materials, namely graphene, atomic resolution three-dimensional imaging of the cellular chemistry will become feasible, which will shed light on various fundamental mechanisms inside the cells. This will provide significant benefits upon success, and will impact a wide spectrum of fields from understanding cellular functions to developing effective drugs.

该项目旨在开发在原子尺度上分析单个生物细胞的新方法。该项目将首先开发一种方法，利用纳米级的离子束以可控的方式与冷冻细胞相互作用，然后进行纳米级的解剖和分析。通过引入工程化的二维材料，即石墨烯，原子分辨率的细胞化学三维成像将成为可能，这将揭示细胞内的各种基本机制。这将在成功后提供显著的好处，并将影响从了解细胞功能到开发有效药物的广泛领域。