RADIOLOGICAL SCIENCES STUDIES WITH ALPHA-CEA

放射科学将提供四个支持领域， 项目 这些包括提供成像，建模的 MAB的药代动力学，辐射剂量的计算， 放射治疗的优化。 项目质量保证 在本部分中也有介绍。 图像最初将 表明相对MAB靶向。 似乎是 然后将在治疗背景下尝试适当的方法， 根据诊断数据计算的辐射剂量， 使用药代动力学分析估计。 因此，我们的四个支持 区域按照逻辑顺序从一个区域进入另一个区域。 密切 与贝蒂医生的手术项目合作将涉及 覆盖各处 与辐射剂量测定小组合作， 橡树岭国家实验室和K.黄某 南加州大学药学院也在计划中。

Radiological Sciences will provide four support areas to the project. These include the provision of imaging, modeling of the pharmacokinetics of the MAB, calculation of radiation doses and the optimization of radiation therapy. Project quality assurance is also described in this part of the proposal. Images will initially indicate relative MAB targeting. Agents which appear to be appropriate will then be tried in a therapeutic context with radiation doses being calculated from the diagnostic data and estimated using pharmacokinetic analysis. Thus, our four support areas lead one into another in a logical sequence. Close collaboration with Dr. Beatty's surgical project will be involved throughout. Collaborations with the radiation dosimetry group at Oak Ridge National Laboratory and with Professor K. Hwang of the USC School of Pharmacy are also planned.