UNIVERSITY OF PENNSYLVANIA SMELL & TASTE CENTER

本申请是请求继续支持 宾夕法尼亚大学气味与味觉研究中心 美国第一个临床研究中心专门致力于 对化学感官的研究。本中心提供 跨学科临床和科学研究的资源和重点 基础研究与理解、诊断、 嗅觉障碍患者的治疗和管理 味觉障碍。来自国家动态医疗中心的数据 CARE调查显示，1975年和1976年加起来，有435,000人 对医生办公室的访问中，一个主要的演示 合规本质上是化学敏感的，该中心是 少数几个国家机构致力于理解和 治疗有这些问题的病人。初级阶段 该中心的行政办公室和诊断设施 位于伊利诺伊州大学医院内 宾夕法尼亚州。中心实验室设在学校内 医学、牙医和兽医，以及 在费城退伍军人管理局医疗中心。 中心新的核心设施，其中中心的 受控环境室和人体空气稀释嗅觉仪 位于，作为中心的主要位置 人体研究，并定位在临床附近 耳鼻咽喉及人类医学系的设施 传播学，神经外科， 牙科医学，以及语言和听力中心。这个素数 地理位置促进了我们中心与这些中心之间的直接互动 以及医院内的其他科室。该中心现已拥有 建立了一个以计算机为基础的病人登记系统，在我们的 设施(根据临床记录，标准化的进食 访谈、医学和感官评估)，提供 为化学感觉病因学研究提供丰富的数据库 疾病、其自然病史、临床表现和 对治疗的反应。在未来五年里，我们将进一步 扩展和分析我们的核心患者数据库，继续我们的 关于嗅觉诊断发展的研究计划 神经内分泌因素对嗅觉的影响及检测 功能。此外，我们将在(A)Low启动新的计划 神经组织的强度激光生物刺激，包括 嗅神经上皮移植，(B)神经解剖学 条件性化学感觉厌恶的底物，(C) 抑郁症与味觉障碍的关系，以及 (D)味觉加工的脑干机制。

This application is a request for continued support of the University of Pennsylvania Smell and Taste Research Center, the first Clinical Research Center in the United State devoted solely to the study of the chemical senses. This Center provides the resources and scientific focus for interdisciplinary clinical and fundamental research related to the understanding, diagnosis, treatment, and management of patients with olfactory and gustatory disorders. Data from the National Ambulatory Medical Care Survey suggest that, for 1975 and 1976 combined, 435,000 visits to physicians'offices occurred in which a major presenting compliant was chemosensory in nature, and this Center is one of the few national institutions devoted to understanding and treating patients with these problems. The primary administrative offices and diagnostic facilities of the Center are located within the Hospital of the University of Pennsylvania. Center laboratories are located within the Schools of Medicine, Dental Medicine, and Veterinary Medicine, as well as in the Veterans Administration Medical Center of Philadelphia. The new Core Facility of the Center, in which the Center's controlled environment room and human air-dilution olfactometer are located, serves as the primary location for the Center's human studies, and is positioned adjacent to the clinical facilities of the Department of Otorhinolaryngology and Human Communication, the Department of Neurosurgery, the Department of Dental Medicine, and the Speech and Hearing Center. This prime location fosters direct interactions between our Center and these and other departments within the Hospital. The Center has now established a computer-based registry of patients studied in our facility (based upon clinical records, standardized intake interviews, and medical and sensory evaluations), providing a rich data base for the study of the etiology of chemosensory disorders, their natural history, clinical manifestations, and response to therapy. During the next five years we will further expand and analyze our core patient data base and continue our research programs on the development of olfactory diagnostic tests and the influences of neuroendocrine factors on olfactory function. In addition, we will initiate new programs on (a) low intensity laser biostimulation of neural tissue, including olfactory neuroepithelial explants, (b) neuroanatomical substrates of conditioned chemosensory aversions, (c) the relation between depressive illness and taste dysfunction, and (d) brainstem mechanisms of gustatory processing.