OXYGEN METABOLITE INITIATED INJURY IN NEONATES

机械通气机辅助吸氧 仍然是婴幼儿和儿童的主要治疗手段 呼吸衰竭。不幸的是，这些干预中的每一个 可能会造成严重的肺损伤，它们的综合影响可能 导致肺功能的永久性损害。目前有 在几个方面努力阐明肺损伤的机制 氧诱导，并开发检测氧毒性的手段 临床上足够早，以帮助最小化或治疗 生病了。氧循环特异性标志物的鉴定 毒性可能是检测早期氧气的最佳手段 毒性。拟议的试点项目将检验这样一个假设： 新生儿暴露在高浓度氧气中会导致 在可检测到的谷胱甘肽二硫化物和 动脉中氧化应激的指示物--脂羟酸 血。此外，还将寻求以下因素之间的相关性 这些标志物的含量和变质程度 肺功能的变化。最后，增加水平的假设 这些物质的含量与慢性肺病的发病率有关 婴儿的疾病将通过跟踪婴儿进行测试 在最初的研究几个月后，临床频繁 肺部症状和功能的评估。

Mechanical ventilation with administration of supplemental oxygen remains the mainstay of treatment of infants and children with respiratory failure. Unfortunately, each of these interventions may produce severe lung damage, and their combined effects may induce permanent impairment of lung function. Currently there are efforts in several areas to elucidate the mechanism of lung injury induced by oxygen, and to develop means to detect oxygen toxicity clinically early enough to aid in minimizing or treating the illness. Identification of specific circulating markers of oxygen toxicity might provide the best means to detect early oxygen toxicity. The proposed pilot project will test the hypothesis that exposure of newborns to high concentrations of oxygen will results in detectably increased concentrations of glutathione disulfide and lipid hydroxy acids, indicators of oxidative stress, in arterial blood. Further, a correlation will be sought between degree of elevation of these markers substances and degree of deterioration of lung function. Finally, the hypothesis that increased levels of these substances correlate with the incidence of chronic lung disease in infants will be tested by following the infants for several months after initial study with frequent clinical assessments of pulmonary symptomatology and function.