ORAL EPIDEMIOLOGY OF INTRAVENOUS DRUG ABUSE

长期目标是观察、记录和分析口语 异性静脉注射吸毒者的疾病。此子项目将 口腔疾病流行病学横断面抽样调查 来自美沙酮维持治疗计划的艾滋病毒+和艾滋病毒静脉注射吸毒者 BIMC&GT；的具体目标是：1)确定口腔疾病的患病率 HIV+静脉注射吸毒者与HIV-IVDU的损害比较；2)确定 坏死性牙周炎和非典型牙周炎(艾滋病毒- HIV+静脉注射吸毒者中的相关性牙周炎和HIV相关性牙周炎：3) 确定急性坏死性溃疡性牙周炎的患病率 (ANUG)HIV+与HIV-IVDU的比较；4)比较探查口袋深度 HIV+和HIV-IVDU中的依恋丧失；5)确定龋病 HIV+与HIV-IVDU的流行率比较；6)确定 口腔病变与T4细胞水平及T4/T8比值的关系 样本。与健康相关：异性恋静脉注射吸毒者 迅速成为主要的艾滋病毒感染人群。初步 研究表明，与艾滋病毒相关的口腔疾病在 静脉注射吸毒者，此外还有猖獗的龋齿和晚期牙周病。它 假设HIV病毒可能通过破损的 并通过牙周组织和裸露的牙髓肆虐 腐烂。因为据报道，许多静脉注射吸毒者吸食“可卡因” 可卡因“会导致无保护的口交，这可能是另一个 传播途径和可能的传染性。这项研究将提供 关于主要人群中艾滋病毒感染的口腔方面的大量数据 感染了病毒。

The long term objectives are to observe, document and analyze oral disease in heterosexual intravenous drug users. This subproject will focus on the oral disease epidemiology of a cross-sectional sample of HIV+ and HIV-IVDUs from the Methadone Maintenance Treatment Program at BIMC> The specific aims are: 1) to determine the prevalence of oral lesions in HIV+ IVDUs compared to HIV- IVDUs; 2) to determine the prevalence of necrotizing periodontitis and atypical gingivitis (HIV- associated periodontitis and HIV-associated gingivitis) in HIV+ IVDUs: 3) to determine the prevalence of acute necrotizing ulcerative gingivitis (ANUG) in HIV+ compared to HIV- IVDUs; 4) to compare probing pocket depth and attachment loss in HIV+ and HIV- IVDUs; 5) to determine the caries prevalence in HIV+ compared to HIV- IVDUs; 6) to determine the relationship between oral lesions and T4 cell levels and T4/T8 ratios in the sample. Health relatedness: Heterosexual intravenous drug users are rapidly becoming a predominant HIV infected population. Preliminary studies indicate the HIV associated oral diseases are prevalent among IVDUs, in addition to rampant decay and advanced periodontal disease. It is hypothesized that HIV virus may be transmitted through breaks in the periodontal tissues and through exposed pulps of teeth with rampant decay. Because it has been reported that many IVDUs smoke "crack cocaine" which can lead to unprotected oral sex, this may be another route of transmission and possible infectivity. This study will provide considerable data on oral aspects of HIV infection in a major population infected with the virus.