ORAL EPIDEMIOLOGY OF INTRAVENOUS DRUG ABUSE

静脉药物滥用的口腔流行病学

• 批准号: 3839382
• 负责人: CHARLES E BARR
• 金额: --
• 依托单位: BETH ISRAEL MEDICAL CTR (NEW YORK)
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3839382
• 关键词: AIDS /HIV test; African American; HIV infections; Hispanic Americans; T lymphocyte; blood chemistry; candidiasis; caucasian American; data collection; dental caries; dental plaque; enzyme linked immunosorbent assay; epidemiology; gingivitis; human immunodeficiency virus 1; human subject; intravenous drug abuse; mouth; oral bacteria; oral leukoplakia; oral mucosa; periodontitis; questionnaires; sex behavior; western blottings

The long term objectives are to observe, document and analyze oral disease in heterosexual intravenous drug users. This subproject will focus on the oral disease epidemiology of a cross-sectional sample of HIV+ and HIV-IVDUs from the Methadone Maintenance Treatment Program at BIMC> The specific aims are: 1) to determine the prevalence of oral lesions in HIV+ IVDUs compared to HIV- IVDUs; 2) to determine the prevalence of necrotizing periodontitis and atypical gingivitis (HIV- associated periodontitis and HIV-associated gingivitis) in HIV+ IVDUs: 3) to determine the prevalence of acute necrotizing ulcerative gingivitis (ANUG) in HIV+ compared to HIV- IVDUs; 4) to compare probing pocket depth and attachment loss in HIV+ and HIV- IVDUs; 5) to determine the caries prevalence in HIV+ compared to HIV- IVDUs; 6) to determine the relationship between oral lesions and T4 cell levels and T4/T8 ratios in the sample. Health relatedness: Heterosexual intravenous drug users are rapidly becoming a predominant HIV infected population. Preliminary studies indicate the HIV associated oral diseases are prevalent among IVDUs, in addition to rampant decay and advanced periodontal disease. It is hypothesized that HIV virus may be transmitted through breaks in the periodontal tissues and through exposed pulps of teeth with rampant decay. Because it has been reported that many IVDUs smoke "crack cocaine" which can lead to unprotected oral sex, this may be another route of transmission and possible infectivity. This study will provide considerable data on oral aspects of HIV infection in a major population infected with the virus.

长期目标是观察，记录和分析口头 异性恋静脉吸毒者的疾病。 该分项目将 重点对口腔疾病流行病学的横断面样本， 来自美沙酮维持治疗计划的HIV+和HIV-IVDU， BIMC>的具体目标是：1）确定口腔疾病的患病率 与HIV- IVDUs相比，HIV+ IVDUs中的病变; 2）确定 坏死性牙周炎和非典型牙龈炎（HIV-1）的患病率 相关的牙周炎和HIV相关的牙龈炎）在HIV+ IVDU：3） 确定急性坏死性溃疡性牙龈炎的患病率 （ANUG）与HIV-IVDU相比; 4）比较探测袋深度 HIV+和HIV- IVDUs中的附着丧失; 5）确定龋齿 与HIV-IVDU相比，HIV+的患病率; 6）确定 口腔病变与T4细胞水平和T4/T8比值之间的关系 示例. 健康相关性：异性恋静脉吸毒者 迅速成为主要的艾滋病毒感染人群。 初步 研究表明，与艾滋病毒相关的口腔疾病在 静脉注射毒品，除了猖獗的腐烂和先进的牙周病。 它 假设HIV病毒可能通过在 牙周组织和通过暴露的牙髓猖獗 腐烂 因为据报道，许多静脉注射吸毒者吸“可卡因”， 可卡因”，这可能会导致无保护的口交，这可能是另一个 传播途径和可能的传染性。 本研究将提供 关于主要人群中艾滋病毒感染的口腔方面的大量数据 感染了病毒