OSTEOPOROSIS--PREVENTION AND TREATMENT

这项建议的长远目标是发展更好的方法， 防治骨质疏松症。 二十六大学 代表九个学科的加州调查人员 开发了六个科学项目（SP）和三个可行性研究 (FS)来实现这一点。 小型实验室、临床、统计和 已经形成了行政核心，以支持这些科学 项目和可行性研究在一个相当大的美元节省。 我们的中心主题是骨质疏松症和骨折预防。 SP #1 研究雌激素给药对 绝经后妇女维生素D代谢和肠道 钙吸收 它应该回答了一个重要的问题， 雌激素增加1，25-二羟维生素D的产生及其游离 血清中的浓度？ SP #2评估内源性酸是否 绝经后妇女的生产有助于阴性 钙平衡，并将决定是否HCO 3管理将 纠正这种异常。 SP #3评估了一种新方法， 分析椎骨的QCT数据， 结构信息，可以准确预测 骨折 SP #4测试准确度、精密度和 新开发的高速（1-2分钟）双 光子吸收扫描仪的革命性设计，以评估骨 多个站点的矿物质含量。 这样的工具具有 解决当前筛查中的主要问题的潜力， 扫描所需的时间。 SP #6测试了一个 相干治疗程序，使用合成甲状旁腺 激素和降钙素，以增加骨矿物质含量， 患有脊柱骨质疏松症的女性患者。 两个FS' 研究基本的骨细胞生物学， 一种雌激素缺乏性骨丢失的人药物诱导模型， 适用于测试具有预防潜力的新药。

The long range goal of this proposal is to develop better ways to prevent and treat osteoporosis. Twenty-six University of California investigators representing nine disciplines have developed six Scientific Projects (SP) and three Feasibility Studies (FS) to accomplish this. Small laboratory, clinical, statistical and administrative cores have been formed to support these Scientific Projects and Feasibility Studies at a considerable dollar savings. Our central theme is osteoporosis and fracture prevention. SP #1 investigates the effect of estrogen administration to postmenopausal women on vitamin D metabolism and intestinal calcium absorption. It should answer the important question, does estrogen increase 1,25-dihydroxyvitamin D production and its free concentration in serum? SP #2 assesses whether endogenous acid production in postmenopausal women contributes to negative calcium balance and will determine if HCO3 administration will correct this abnormality. SP #3 evaluates a new approach to analyzing QCT data of vertebra which could provide key structural information that would permit accurate prediction of fracture. SP #4 tests the accuracy, precision and the applicability of a newly developed high speed (1-2 min) dual photon absorption scanner of revolutionary design to assess bone mineral content at multiple sites. Such an instrument has the potential of solving the major current problem in screening, that of the time required for scanning. SP #6 tests the ability of a coherence treatment program, using synthetic parathyroid hormone and calcitonin, to increase bone mineral content in women patients with established spinal osteoporosis. Two FS' investigate basic bone cell biology and one will evaluate whether a human drug induced model of estrogen deficiency bone loss is suitable for testing new drugs with prophylactic potential.