GROWTH AND NUTRITION OF NORMAL INFANTS

我们的长期目标是发展对增长的更好理解 以及足月儿和早产儿的营养。我们希望建立营养 要求并探讨正常新陈代谢的某些方面 婴儿。全世界很少有其他实验室能做到这一点 重点是对正常婴儿的研究。对于足月儿和早产儿，我们希望 直接法和间接法测量能量平衡方法的比较 量热法、心跳计数和双标记水，以供探索 早产儿能量平衡与饮食、身体的关系 组成，并确定喂养方式的效果(母乳或 公式)对能量消耗的影响。我们将获得新的估计 足月儿对苯丙氨酸和酪氨酸的需要量。我们会 确定铁、铜和铜之间是否发生不利的相互作用 在膳食摄入量范围内的锌可能会被 婴儿。利用锌的稳定同位素，我们将研究主要的 影响锌吸收的因素。我们将确定年龄的影响 对氟的吸收、排泄和滞留，时机的影响 摄入氟化物剂量(一次喂食或两次喂食之间) 氟的吸收和滞留，以及铁的影响，我们将 确定铁保留率与并入的关系 留存的铁进入红细胞。我们将探索影响因素 铁强化婴幼儿食品中铁残留的研究 预防缺铁的策略。我们将探索婴儿S 通过BALANCE研究和生物素评价对生物素的需求 营养状况与膳食中生物素摄入量的关系。

Our long-term goal is the development of a better understanding of growth and nutrition of term and preterm infants. We wish to establish nutrient requirements and to explore certain aspects of metabolism of normal infants. Few other laboratories throughout the world are similarly focused on studies of normal infants. In term and preterm infants we wish to compare methods of measuring energy balance by direct and indirect calorimetry, heart beat counting and doubly-labeled water, to explore in preterm infants the relation between energy balance, diet and body composition, and to determine the effect of feeding mode (breast or formula) on energy expenditure. We shall obtain new estimates of the requirements for phenylalanine plus tyrosine in term infants. We shall determine whether adverse interactions occur between iron, copper and zinc within the range of dietary intakes likely to be encountered by infants. Using stable isotopes of zinc, we shall investigate the major factors influencing zinc absorption. We shall determine the effect of age on fluoride absorption, excretion and retention, the effect of timing of administration of a fluoride dose (with a feeding or between feedings) on fluoride absorption and retention, and the effect of iron, we shall determine the relation between iron retention and incorporation of retained iron into erythrocytes. We shall explore factors influencing iron retention from iron-fortified infant foods in an attempt to develop strategies for preventing iron deficiency. We shall explore the infant;s requirement for biotin by balance studies and by evaluation of biotin nutritional status in relation to dietary intake of biotin.