GROWTH AND NUTRITION OF NORMAL INFANTS

我们的长期目标是更好地理解增长 和早产儿的营养。我们希望建立营养 要求，并探讨正常代谢的某些方面， 婴儿。世界上很少有其他实验室类似 专注于对正常婴儿的研究在足月和早产儿中，我们希望 比较直接和间接测量能量平衡的方法 量热法，心跳计数和双标记水，探索在 早产儿能量平衡、饮食与身体的关系 组成，并确定喂养模式（乳房或乳房）的影响， （1）能量消耗。我们将获得新的估计， 对苯丙氨酸加酪氨酸的需求。我们将 确定铁、铜和铁之间是否发生不良相互作用， 锌在饮食摄入量的范围内可能会遇到 婴儿。利用锌的稳定同位素，我们将研究 影响锌吸收的因素我们将确定年龄的影响 对氟的吸收、排泄和存留的影响， 给予氟化物剂量（与喂养或喂养之间） 氟的吸收和保留，以及铁的影响，我们将 确定铁保留和结合之间的关系 保留铁进入红细胞。我们将探讨影响 铁强化婴儿食品中的铁保留， 预防缺铁的策略。我们将探索婴儿; 平衡研究和生物素评价对生物素的要求 营养状况与生物素膳食摄入量有关。

Our long-term goal is the development of a better understanding of growth and nutrition of term and preterm infants. We wish to establish nutrient requirements and to explore certain aspects of metabolism of normal infants. Few other laboratories throughout the world are similarly focused on studies of normal infants. In term and preterm infants we wish to compare methods of measuring energy balance by direct and indirect calorimetry, heart beat counting and doubly-labeled water, to explore in preterm infants the relation between energy balance, diet and body composition, and to determine the effect of feeding mode (breast or formula) on energy expenditure. We shall obtain new estimates of the requirements for phenylalanine plus tyrosine in term infants. We shall determine whether adverse interactions occur between iron, copper and zinc within the range of dietary intakes likely to be encountered by infants. Using stable isotopes of zinc, we shall investigate the major factors influencing zinc absorption. We shall determine the effect of age on fluoride absorption, excretion and retention, the effect of timing of administration of a fluoride dose (with a feeding or between feedings) on fluoride absorption and retention, and the effect of iron, we shall determine the relation between iron retention and incorporation of retained iron into erythrocytes. We shall explore factors influencing iron retention from iron-fortified infant foods in an attempt to develop strategies for preventing iron deficiency. We shall explore the infant;s requirement for biotin by balance studies and by evaluation of biotin nutritional status in relation to dietary intake of biotin.