BRAIN EDEMA CLINICAL RESEARCH CENTER

脑水肿临床研究中心

• 批准号: 3099470
• 负责人: ROBERT A. FISHMAN
• 金额: $ 56.48万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-07-01 至 1991-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3099470
• 关键词: brain edema; cerebral ischemia /hypoxia

Brain edema is the major response of the central nervous system to heterogenous pathological disorders (spinal cord edema shares similar mechanisms) including trauma, hypoxia, ischemia, infections, tumors, as well as metabolic disorders including liver failure, status epilepticus, osmotic derangements, and Reye's syndrome. The research program of the Brain Edema Clinical Research Center provides for interdisciplinary studies ranging from the biochemical, ultrastructural and physiological basis of various types of brain edema to pharmacological and clinical studies. The program includes core budgets and 7 projects as follows: Project 1. Molecular Mechanisms and Metabolic Basis of Brain Edema. Project 2. Mitochondrial Function in Brain Edema. Project 3. Spinal Cord Edema After Trauma and Ishemic Injury. Project 4. Cell Excitation and Calcium Accumulation in Cellular (Cytotoxic) Brain Edema. Project 5. Glycogen Metabolism and Brain Edema. Project 6. N.M.R. Studies of Energy Metabolism in Ischemic Brain Edema. Project 7. Clincal Studies: Naloxone in Human Head Injury. It is the overall goal of the Center to enable the several laboratories to work individually and together to broaden knowledge of the fundamental mechanisms of the various forms of brain edema with the intention of bringing such investigations to clinical application in the improved treatment of patients with brain and spinal cord edema.

脑水肿是中枢神经系统对 异质性病理障碍(脊髓水肿有相似之处 机制)包括创伤、缺氧、缺血、感染、肿瘤、AS 以及代谢紊乱，包括肝功能衰竭，癫痫持续状态， 渗透性紊乱和雷伊氏综合征。该中心的研究计划 脑水肿临床研究中心提供跨学科研究 从生化、超微结构和生理基础等方面 对各种类型的脑水肿进行药理和临床研究。这个 方案包括核心预算和7个项目，具体如下： 项目1。脑水肿的分子机制和代谢基础。 项目2：脑水肿中的线粒体功能。 项目3.创伤和缺血性损伤后的脊髓水肿。 项目4.细胞兴奋和细胞内钙积累(细胞毒性) 脑水肿。 项目5.糖原代谢与脑水肿。 项目6：《脑缺血性水肿能量代谢研究》。 项目7：临床研究：纳洛酮治疗人类头部损伤。 该中心的总体目标是使几个实验室能够 单独和共同努力，扩大对基础知识的了解 不同形式脑水肿的发病机制 将这种研究带入临床应用的改进 脑和脊髓水肿患者的治疗。