PSYCHOPHARMACOLOGICAL STUDY OF PSYCHIATRIC DISORDERS

某精神卫生临床研究中心住院患者研究单位 情感障碍是在加州大学阿肯色州分校 圣地亚哥和圣地亚哥退伍军人管理局医疗中心。 这个临床研究单位由一名MHCRC研究骨干人员扩充 面向协调人员和支持护士、心理技术人员 和实验室人员，并提供核心的综合服务 MHCRC调查人员。在一个新加强的科学咨询的指导下 委员会，MHCRC的科学努力一直专注于 行为-心理药理学-心理生物界面。这次会议的重点是 中心致力于情感障碍的研究，使用精神病患者， 正常对照组和住院对照组。我们正在继续我们的研究，描绘出 胆碱能功能和神经激素反应的差异 毒扁豆碱在情感性精神障碍患者亚型中的作用 这些变化与肾上腺素能和5-羟色胺能变量的关系。我们 正在继续我们的工作，探索内源性阿片类药物 多肽对情感障碍有调节作用，使用美沙酮和 纳洛酮作为调查工具。我们正在学习时间生物学和 情感障碍的光周期论。此外，我们正在应用一种高 风险-低风险策略对潜在的潜在标记物的研究 情感障碍。我们正在研究潜在的行为机制 三环类抗抑郁药和其他神经亲和性药物对正常人和 影响精神障碍患者，并正在研究各种精神药物的效果 药物和电疗对记忆和认知加工的影响。我们与中国的关系 加州大学圣地亚哥分校精神病学系的基础科学家，致力于 项目采用动物模型，具有很强的互补性。在 在上述框架下，多项合作正在进行。

A mental Health Clinical Research Center inpatient research unit to study affective disorders has been developed at the University of California at San Diego and at the San Diego Veterans Administration Medical Center. This clinical research unit is augmented by a cadre of MHCRC research oriented coordinating personnel and support nurses, psychology technicians and laboratory personnel, and provides a core of integrative services to MHCRC investigators. Guided by a newly strengthened scientific advisory committee, the MHCRC scientific effort has focused on the behavioral-psychopharmacologic-psychobiologic interface. The focus of the Center is on the study of affect disorders, using psychiatric patients, normals and inpatient controls. We are continuing our studies delineating differences in cholinergic function and neurohormonal response to a physostigmine challenge in subtypes of affective disorder patients and the relationship of these changes to adrenergic and serotonergic variables. We are continuing our work exploring the hypothesis that endogenous opioid polypeptides are regulatory in affective disorders, using methadone and naloxone as investigative tools. We are studying chronobiologic and photoperiodism aspects of affective disorder. Also, we are applying a high risk-low risk strategy to the study of potential prospective markers of affective disorder. We are studying behavioral mechanisms underlying tricyclic antidepressant and other neurotropic drug effects in normals and affect disorder patients, and are studying effects of various psychotropic drugs and ECT on memory and cognitive processing. Our relationship with basic scientists in the UCSD Department of Psychiatry, working on allied projects using animal models, is strong and mutually enriching. Within the above framework, multiple collaborations are proceeding.