Role of fatty acid chain length in energy balance and adaptive thermogenesis

脂肪酸链长度在能量平衡和适应性产热中的作用

• 批准号: BB/H002731/1
• 负责人: Antonio Vidal-Puig
• 金额: $ 65.42万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FH002731%2F1
• 关键词: Role; fatty; acid; chain; length

Food contains different types of fat. There are some suggestions that not all the fats are equal and that there is good and bad fat with respect to their effects in the body. Not too much is known about what fat normally does in the cells of the body. We know that fat can be stored, burned, been sent from one organ to another within the body and more importantly fat are important 'bricks' to build up the different components of the cells. Interestingly not all the fats have the same size, the length of some fats is longer than others and we think that the length of the fat species may be an important determinant whether fat is stored or burn. The best organ to study this is a special type of organ known as brown fat present in children and small animals. This organ can do both, making fat and burning fat so it is the ideal organ to investigate the effect of fat length on these two processes. To study fat length we will investigate the effect of lack and/or excess of Elovl6, a molecule that elongates fat from 12 carbons to 18 carbons. Specifically we propose to investigate: 1) if making fat longer can alter the development of the brown fat organ; b) whether eliminating/increasing the capacity of elongating fat makes the animals fatter/leaner and c) less/more capable of making heat. To that end we will use cells and mice in which we will decrease or increase the capacity to make fat longer and then study the type of fat these animals make using very novel techniques that allow us to know all the types of fats that these animals will have. This information will inform us about which fats are good and which ones are bad and will allow us, for example, to modify the diets of humans and animals to ensure that they have the right type of fats to remain healthy.

食物含有不同种类的脂肪。有些人认为并不是所有的脂肪都是一样的，根据它们对身体的影响有好脂肪和坏脂肪之分。人们对脂肪在人体细胞中的正常作用知之甚少。我们知道，脂肪可以储存、燃烧，从体内的一个器官输送到另一个器官，更重要的是，脂肪是构建细胞不同组成部分的重要“砖块”。有趣的是，并不是所有的脂肪都有相同的大小，一些脂肪的长度比其他脂肪长，我们认为脂肪种类的长度可能是脂肪是储存还是燃烧的重要决定因素。研究这一问题的最佳器官是儿童和小动物中存在的一种被称为棕色脂肪的特殊器官。这个器官既能制造脂肪又能燃烧脂肪，所以它是研究脂肪长度对这两个过程影响的理想器官。为了研究脂肪长度，我们将研究elov16的缺乏和/或过量的影响，elov16是一种将脂肪从12个碳延长到18个碳的分子。具体来说，我们建议研究：1)延长脂肪是否会改变棕色脂肪器官的发育；B)消除/增加延长脂肪的能力是否会使动物更胖/更瘦；c)产生热量的能力更少/更强。为此，我们将使用细胞和老鼠，我们将减少或增加这些动物制造脂肪的能力，然后研究这些动物制造的脂肪类型，使用非常新颖的技术，使我们能够知道这些动物将拥有的所有类型的脂肪。这些信息将告诉我们哪些脂肪是好的，哪些是坏的，并将允许我们，例如，调整人类和动物的饮食，以确保他们有正确的脂肪类型来保持健康。

项目成果

Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease.

• DOI: 10.1002/hep.28953
• 发表时间: 2017-04
• 期刊: Hepatology (Baltimore, Md.)
• 作者: Hall Z;Bond NJ;Ashmore T;Sanders F;Ament Z;Wang X;Murray AJ;Bellafante E;Virtue S;Vidal-Puig A;Allison M;Davies SE;Koulman A;Vacca M;Griffin JL
• 通讯作者: Griffin JL

PPARs and Metabolic Disorders Associated with Challenged Adipose Tissue Plasticity.

PPAR 和与脂肪组织可塑性受损相关的代谢紊乱。

• DOI: 10.17863/cam.58415
• 发表时间: 2018
• 作者: Corrales P

Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity.

Insig1/SREBP1/SCD1 设定点的适应性变化有助于脂肪组织应对肥胖增加的储存需求。

• DOI: 10.17863/cam.64978
• 发表时间: 2013
• 作者: Carobbio S