REGIONAL CEREBRAL BLOOD FLOW IN PROGRESSIVE DEMENTIA

这项研究的主要长期目标是提供一个 安全、非侵入性、经济有效的神经生物学方法 阿尔茨海默病与多发性痴呆的鉴别与鉴别 梗死性痴呆症和抑郁症。目前，差额 阿尔茨海默病的诊断是推定的、昂贵的、时间 消耗，而且经常不准确，唯一明确的 诊断来自对脑组织的检查。海流 项目被设计为确定 脑皮质局部血流量的测量 133Xe吸入技术可以作为一种诊断以及一种 预后预测方法。另一个目标是研究 进展性脑损伤过程中的动态皮质功能 阿尔茨海默病、多发性梗死性痴呆和抑郁症。是这样的 数据可能具有预测价值。成功完成这项工作 研究将增加一种具有成本效益的非侵入性神经生物学 工具连接到差动诊断电池。 在这个最初的项目中，阿尔茨海默病患者群体， 多发性梗死性痴呆症、抑郁症和正常受试者 在休眠和记忆任务期间对 最少四次：最初，此后每年。 每个患者/受试者还将接受全面的 神经心理测试组合和神经学检查 每一次测量的日期。休息和激活 将分析rCBF以确定是否存在独特的血流 不同病症的模式。神经心理测验 数据将与静止和激活的流程相关联，以进一步 阐明在每个过程中大脑-行为的关系 无序。本方案中研究的患者/受试者将 通过后续的研究项目继续跟踪， 在他们各自的疾病过程中有明确的 尽可能通过尸检获得诊断。

The major long-term objective of this research is to provide a safe, noninvasive, cost-effective neurobiological method of identifying and distinguishing Alzheimer's Disease from multi- infarct dementia and depression. Currently, the differential diagnosis of Alzheimer's disease is presumptive, costly, time consuming, and frequently inaccurate with the only unequivocal diagnoses coming from examination of brain tissue. The current project is designed as the first step in determining whether the measurement of cortical regional cerebral blood flow via the 133Xe inhalation technique can serve as a diagnostic as well as a prognostic method. Another objective is to study the changes in dynamic cortical functioning during the progressive course of Alzheimer's disease, multi-infarct dementia and depression. Such data could be of prognostic value. Successful completion of this research would add a cost effective, noninvasive neurobiological tool to the differential diagnostic battery. In this initial project, groups of patients with Alzheimer's disease, multi-infarct dementia, depression and unimpaired subjects will undergo rCBF measurements during rest and memory tasks on a minimum of four occasions: initial, and annually thereafter. Each patient/subject will also undergo a comprehensive neuropsychological test battery and a neurological examination on the day of each of these measurements. Resting and activated rCBF will be analyzed to determine if there are unique blood flow patterns for the respective disorders. The neuropsychological test data will be correlated with resting and activated flow to further elucidate brain-behavior relationships during the course of each disorder. The patients/subjects studied in this protocol will continue to be followed, through subsequent research projects, throughout the course of their respective disorders with definitive diagnoses being obtained via autopsy whenever possible.