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Investigating the mechanisms controlling contraction in the first skeletal muscle displaying intrinsic pace maker properties

研究控制显示内在起搏器特性的第一骨骼肌收缩的机制

基本信息

批准号：
BB/H01022X/1
负责人：
Ketan Patel
金额：
$ 44.98万
依托单位：
University of Reading
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2010
资助国家：
英国
起止时间：
2010 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FH01022X%2F1
关键词：
Investigating mechanisms controlling contraction first

项目摘要

Even when removed from the body, the human heart will continue to beat (contract). However, in contrast, when a normal muscle is taken out of the body, it will not contract unless externally stimulated in some manner (e.g. electrical stimulation). We have recently found a very special skeletal muscle that goes against this central biological principle. This muscle is called the lymph heart and it beats even though it is not linked to any nerves. We want to carry out research to understand what allows this muscle to contract when it should not really be able to do so. In particular, we want to look at the molecules that allow it to make its own electrical signal and find out how this electrical signal spreads across the muscle to enable contraction and so to function as a pump. We believe that this muscle represents an intermediate form of tissue that shows features of both heart and muscle. At present we know very little about this muscle and investigations into the working of this tissue will be of great interest and use to scientists studying both of these tissues. We believe that a strong basic understanding of this tissue, may enable us and others to engineer muscle into self-contracting tissues like the heart, thereby opening new avenues for developing treatment in heart and muscular diseases.

即使离开身体，人的心脏仍会继续跳动（收缩）。然而，相反，当正常肌肉被取出体外时，除非以某种方式受到外部刺激（例如电刺激），否则它不会收缩。我们最近发现了一种非常特殊的骨骼肌，它违背了这一核心生物学原理。这块肌肉被称为淋巴心脏，即使它不与任何神经相连，它也会跳动。我们想要进行研究，以了解是什么让这块肌肉在实际上不应该收缩的情况下收缩。特别是，我们希望研究允许其产生自己的电信号的分子，并找出该电信号如何在肌肉中传播以实现收缩，从而起到泵的作用。我们相信这种肌肉代表了一种中间形式的组织，显示出心脏和肌肉的特征。目前我们对这种肌肉知之甚少，对这种组织工作原理的研究将对研究这两种组织的科学家产生极大的兴趣和用途。我们相信，对这种组织的深入了解，可能使我们和其他人能够将肌肉设计成像心脏这样的自收缩组织，从而为开发心脏和肌肉疾病的治疗开辟新途径。