Chemo-sensation in Ascaris infection

蛔虫感染中的化学感觉

• 批准号: DP180102049
• 负责人: A/Prof Aaron Jex
• 金额: $ 43.87万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-06-30 至 2022-12-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180102049
• 关键词: Chemo; sensation; Ascaris; infection

This project aims to show the role of chemo-sensation as an equally important target for worm control, and explore pathways to prevent infection. Parasitic worms cost global food/textile industry more than $100 billion dollars per year, and cause disease in more than 1 billion people and domesticated animals world-wide. This project will use a combination of imaging, systems biology, chemical biology and microfluidic methods to provide significant benefits, such as exploring Ascaris chemo-sensation during larval migration, identify the key host queues and parasite genes regulating this process, and probe helminth chemosensation as a novel target for anti-parasitic treatments.

该项目旨在展示化学感觉作为蠕虫控制的同等重要的目标的作用，并探索预防感染的途径。寄生蠕虫每年给全球食品/纺织工业造成超过1000亿美元的损失，并在全球范围内导致超过10亿人和驯养动物的疾病。该项目将使用成像，系统生物学，化学生物学和微流体方法的组合来提供显着的好处，例如探索蛔虫幼虫迁移期间的化学感觉，确定调节这一过程的关键宿主队列和寄生虫基因，并将蠕虫化学感觉作为抗寄生虫治疗的新靶点。