DEFECTIVE EXPRESSION OF HLA-DR BETA GENES

HLA-DR β 基因的表达缺陷

• 批准号: 3134609
• 负责人: ROBERT W KNOWLES
• 金额: $ 12.95万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-09-01 至 1990-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3134609
• 关键词: antibody formation; antibody specificity; beta globulin; complementary DNA; electrofocusing; gel electrophoresis; gene expression; gene frequency; gene mutation; genetic disorder; genetic manipulation; histocompatibility antigens; histocompatibility gene; human population genetics; human subject; hybridomas; immunoglobulin genes; immunoprecipitation; laboratory mouse; major histocompatibility complex; molecular cloning; molecular genetics; monoclonal antibody; mutagen testing; nucleic acid hybridization; nucleic acid probes; nucleic acid sequence; serology /serodiagnosis; transfection

项目成果

An altered splice site is found in the DRB4 gene that is not expressed in HLA-DR7,Dw11 individuals.

在 DRB4 基因中发现了一个改变的剪接位点，该基因在 HLA-DR7、Dw11 个体中不表达。

• DOI: 10.1007/bf00352841
• 发表时间: 1989
• 期刊: Immunogenetics
• 影响因子: 3.2
• 作者: Sutton,VR;Kienzle,BK;Knowles,RW
• 通讯作者: Knowles,RW

Mapping of a restriction fragment length polymorphism associated with defective DR beta 4 chain expression to the HLA-DRB1 gene.

与 DR beta 4 链表达缺陷相关的限制性片段长度多态性映射到 HLA-DRB1 基因。

• DOI: 10.1016/0198-8859(88)90042-0
• 发表时间: 1988
• 期刊: Human immunology
• 影响因子: 2.7
• 作者: Sutton,VR;Knowles,RW
• 通讯作者: Knowles,RW