VIRUS-INDUCED IMMUNOPATHOLOGY

将在小鼠身上检测病毒诱导的T细胞反应刺激 感染几种病毒中的任何一种，包括淋巴细胞性 脉络膜脑膜炎、小鼠巨细胞增多症、牛痘、匹辛德和流感 病毒。病毒诱导的同种异体特异性细胞毒性T细胞(CTL)刺激 在C57BL/6小鼠中将检查关于靶标特异性、遗传 诱导的要求、与其他CTL的关系以及由 可溶的因素。病毒诱导的病毒特异性CTL的T细胞受体 同种异体特异性CTL和常规诱导的同种异体CTL 比较一下。类似地，在第二种多克隆CTL诱导模型中，通过 病毒，由感染病毒而激活的病毒特异性记忆CTL 将对抗原性不同的病毒进行检查。在某些序列中 病毒感染是一种疾病，通常情况下这两种病毒都不会导致这种疾病 归纳。这与单个核细胞的浸润和坏死有关。 内脏脂肪。与这种坏死相关的细胞反应将 被识别并与急性病毒感染的性质相关 以多克隆方式激活CTL。在人类中，病毒感染一直是 与同种异体移植排斥反应、肿瘤缓解和 自身免疫力。病毒诱导的多克隆CTL机制的研究 刺激可能有助于理解这些潜在的病理 病毒感染的后遗症。

Virus-induced stimulation of T cell responses will be examined in mice infected with either of several viruses, including lymphocytic choriomeningitis, murine cytomegalo, vaccinia, Pichinde, and influenza viruses. Virus-induced stimulation of allospecific cytotoxic T cells (CTL) in C57BL/6 mice will be examined in regard to target specificity, genetic requirements for induction, relationship with other CTL, and regulation by soluble factors. The T cell receptors of virus-specific CTL, virus-induced allospecific CTL, and conventionally induced allospecific CTL will be compared. Similarly, in a second model of polyclonal CTL induction by viruses, the activation of virus specific memory CTL by infections with antigenically distinct viruses will be examined. In certain sequences of virus infection a disease results which neither virus alone would normally induce. This is associated with mononuclear cell infiltration and necrosis of visceral fat. The cellular responses associated with this necrosis will be identified and correlated to the property of the acute virus infections to polyclonally activate CTL. In man, virus infections have been associated with allograft rejections, tumor remissions, and development of autoimmunity. Studying the mechanism of virus-induced polyclonal CTL stimulation may help in the understanding of these potent pathological sequelae of virus infections.