TESTING OF ADAPTIVE BONE CHANGE HYPOTHESES

适应性骨变化假设的检验

• 批准号: 3160971
• 负责人: James B Koeneman
• 金额: $ 9.25万
• 依托单位: HARRINGTON ARTHRITIS RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-01 至 1993-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3160971
• 关键词: arthroplasty; bone density; computer simulation; dogs; environmental adaptation; femur; fracture fixation; histology; joint prosthesis; mechanical stress; morphology; skeletal prosthesis

DESCRIPTION: (Adapted from investigator's abstract) The purpose of this study is to correlate bone changes which have occurred in an animal study with the calculated stress patterns which exist in the cancellous bone. The emphasis of the study is to find the simplest usable stress-bone density relationship which predicts long term bone changes around total joint replacements, fracture fixation devices and osteotomies. In addition, detailed bone histormorphometry will be performed to see if the bone changes represent a stable equilibrium condition and to provide information on biological mechanisms which can be used to develop better theoretical models. The specific aims of this study are to: (1) measure the cancellous bone density throughout retrieved dog femora, both with and without implants in them; (2) perform sophisticated finite element stress analyses of the femora; and (3) perform a regression analysis between various stress parameters and bone density. Back scattered electron imaging and quantitative bone histomorphometry will be used to characterize the cancellous bone. A detailed 3-D finite element stress analysis will be used to determine the stress distributions.

描述：（改编自研究者摘要） 研究是将动物研究中发生的骨变化与 与计算的应力模式存在于松质骨。 研究的重点是寻找最简单的可用应力骨 密度关系，可预测总骨密度周围的长期骨变化 关节置换、骨折固定装置和截骨术。 在 此外，将进行详细的骨历史形态测量，以观察 骨变化代表稳定的平衡状态， 关于生物机制的信息，可用于更好地开发 理论模型。 本研究的具体目的是：（1）测量 整个取出的犬股骨的松质骨密度， 没有植入物;（2）执行复杂的有限元应力 股骨的分析;以及（3）在以下各项之间进行回归分析： 各种应力参数和骨密度。 背散射电子 将使用成像和定量骨组织形态计量学来表征 松质骨 详细的三维有限元应力分析将 用于确定应力分布。