FATIQUE OF BONE RELATIONSHIPS TO EXERCISE

这个项目旨在更全面地理解疲劳。 失败，因为它发生在骨骼和不同的关系 运动方案对骨的力学和几何参数的影响 以及骨骼对这些运动计划的生物反应。自.以来 疲劳骨折和疲劳损伤如此频繁地发生，希望 调查人员认为，可以开始个人锻炼计划 预防和/或治疗骨骼疲劳损伤。作者建议使用 将马作为疲劳失效的自发模型，并对其进行测试 高应变运动导致骨骼硬度降低的假说 在体内，就像它在体外所做的那样。对这种高毒株的生物反应 在年轻人身上是针对改变人的惯性属性的 骨骼，使骨骼重塑，以重建骨骼的结构。这个 作者提出了利用图像重建骨骼骨折损伤的方法 分析了允许2平面重建的技术。测量 在体骨应变将在疲劳破坏前后完成。 骨骼建模和重建将使用骨骼标签和 钙化组织学。将在活体内监测骨骼硬度的变化 使用应变计仪器。用四点法进行体外测量 将进行弯曲测试，并将其与预测测量结果进行比较 材料和惯性特性的计算机断层扫描数据 正常骨骼和那些遭受高应变循环疲劳的人。

This project is directed at a more complete understanding of fatigue failure as it occurs in bone and at the relationships that different exercise regimens have on the mechanical and geometric parameters of bone and the biological reaction of bone to these exercise programs. Since fatigue fractures and fatigue injury occur so frequently it is the hope of the investigators that individual exercise programs could be started to prevent and/or treat fatigue injuries of bone. The authors propose to use the horse as a spontaneous model of fatigue failure and to test the hypothesis that high strain exercise caused decreased stiffness in bone in vivo much as it does in vitro. The biological reaction to this high strain in young individuals is directed at changing the inertial properties of the bone to allow bone remodeling to reconstitute the bone's architecture. The authors propose to reconstruct the fracture injury in bone using image analyses techniques to allow for 2-plane reconstructions. Measurement of in vivo bone strain will be accomplished before and after fatigue failure. Bone modeling and remodeling will be examined using bone labels and calcified histology. Changes in bone stiffness will be monitored in vivo using strain gage instrumentation. In vitro measurements using 4-point bending tests will be made and compared to predicted measurements using data from computed tomography scans of material and inertial properties in normal bones and in those subjected to high strain cyclic fatigue.