STRUCTURE AND FUNCTION OF SARCOPLASMIC RETICULUM

肌肉结构与功能研究的新进展 肌浆网导致了分子成分的分解 参与Ca 2离子转运。 然而，人们对此知之甚少。 钙离子从肌浆网释放的机制， 可能是肌肉收缩的关键过程。 为了获得更多的 了解钙离子转运和释放的分子机制， 我们计划研究肌浆网的分子结构和分布， 蛋白质的某些膜成分，即ATP酶， 钙螯合蛋白和糖蛋白;以及这些组分与 磷脂，以重建能够转运Ca 2离子的囊泡 并在生理条件下释放。

Recent developments in the study of the structure and function of muscle sarcoplasmic reticulum have led to the resolution of molecular components involved in Ca2 ion transport. Very little is known, however, about the mechanism by which Ca2 ion is released from the sarcoplasmic reticulum, which presumably is a key process in muscle contraction. In order to gain further understanding of the molecular mechanism of Ca2 ion transport and release in the sarcoplasmic reticulum, we plan to study the molecular structure and disposition of some membrane components of the protein, viz. the ATPase enzyme, calsequestrin and glycoprotein; and the interaction of these components with phospholipids in an effort to reconstitute vesicles capable of Ca2 ion transport and release under physiological conditions.