课题基金 / 基金详情

MECHANISM OF HORMONAL CONTROL OF MAMMARY CARCINOMA

MECHANISM OF HORMONAL CONTROL OF MAMMARY CARCINOMA
乳腺癌的激素控制机制
批准号：
3163463
负责人：
WILLIAM L MC GUIRE
金额：
$14.08万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
1977
资助国家：
美国
项目状态：
已结题
起止时间：
1977-12-01 至 1987-11-30
来源：
https://reporter.nih.gov/project-details/3163463
关键词：
breast neoplasms carcinoma estrogen inhibitor gel electrophoresis genetic translation histochemistry /cytochemistry hormone regulation /control mechanism hormone related neoplasm /cancer human tissue hybridomas lactation mammary gland messenger RNA monoclonal antibody pregnancy preneoplastic state progesterone radioimmunoassay radiotracer tissue /cell culture

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中文摘要
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英文摘要
The aim of this proposal is to prepare monoclonal antibodies against the human breast cancer cell protein 24k. The antibodies will be prepared by the methodology of Kohler and Milstein and be used to establish a radioimmunoassay for 24k in breast cancer biopsies. A study will be done to compare estrogen and progesterone receptor with 24k in predicting responsiveness to endocrine therapy of breast cancer. The antibodies will also be used to select subsets of breast cancer tissue culture cells particularly responsive to estradiol.
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