LYME DISEASE--DEVELOPMENT OF SKIN LESIONS AND ARTHRITIS

莱姆病——皮肤损伤和关节炎的发展

基本信息

  • 批准号:
    3157452
  • 负责人:
  • 金额:
    $ 12.77万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1985
  • 资助国家:
    美国
  • 起止时间:
    1985-09-23 至 1994-02-28
  • 项目状态:
    已结题

项目摘要

Lyme disease is caused by infection with a spirochete, Borrelia burgdorferi which is transmitted by the bite of Ixodes ticks. It is characterized by an annular skin lesion, usually starting at the site of tick attachment, known as erythema chronicum migrans (ECM) and, in decreasing order of frequency, by arthritis usually of the large joints, neurological and cardiac complications. The pathogenic relationships between infection with the Lyme disease spirochete and the development of lesions in the skin, heart, brain and joints are just beginning to be understood. Although the disease has many symptoms and may become chronic, very few spirochetes are found in Lyme disease patients. The hypothesis that the pathogenesis of this disease results from biological amplification of the effects of small numbers of organisms through the release of highly active spirochetal products or from the production of endogenous mediators of tissue injury, or both, will be investigated. In the present studies pathogenic components of B. burgdorferi will be examined. In so doing a more general understanding of bacterial pathogenesis and especially of bacteria-induced arthritis should result. Bacterial lipopolysaccharides (LPS) and peptidoglycans (PG) from the cell wall have been shown to mediate tissue damage. B. burgdorferi LPS and PG will be extracted and characterized with respect to their physicochemical, immunological and biological properties. Sugar and lipid moieties of the LPS will be identified as will the amino acid composition of the PG. LPS from cultured and freshly isolated spirochetes will be compared. Antibodies specific for LPS and PG will be used to neutralize the biological activities of these molecules. Monoclonal anti-LPS antibodies will be used to identify the epitopes responsible for the inflammatory actions of LPS and to locate the LPS using immunogold labeling and electron microscopy. Inflammatory lesions produced in animal skins following injection of PG or LPS will be characterized with respect to morphology and induction of endogenous mediators of inflammation. A rat model of Lyme arthritis will be investigated for the roles of LPS and PG in arthritogenesis.
莱姆病是由螺旋体伯氏疏螺旋体感染引起的

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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GAIL S HABICHT其他文献

GAIL S HABICHT的其他文献

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{{ truncateString('GAIL S HABICHT', 18)}}的其他基金

IRB ADMINISTRATION AND MANAGEMENT: A Paperless Approach
IRB 行政和管理:无纸化方法
  • 批准号:
    6591180
  • 财政年份:
    2002
  • 资助金额:
    $ 12.77万
  • 项目类别:
SBU and SUNY-Wide Enhanced Educational Outreach
SBU 和纽约州立大学范围内加强教育推广
  • 批准号:
    6777802
  • 财政年份:
    2002
  • 资助金额:
    $ 12.77万
  • 项目类别:
LYME DISEASE: DEVELOPMENT OF SKIN LESIONS AND ARTHRITIS
莱姆病:皮肤损伤和关节炎的发展
  • 批准号:
    3157446
  • 财政年份:
    1985
  • 资助金额:
    $ 12.77万
  • 项目类别:
LYME DISEASE: DEVELOPMENT OF SKIN LESIONS AND ARTHRITIS
莱姆病:皮肤损伤和关节炎的发展
  • 批准号:
    3157449
  • 财政年份:
    1985
  • 资助金额:
    $ 12.77万
  • 项目类别:
LYME DISEASE: DEVELOPMENT OF SKIN LESIONS AND ARTHRITIS
莱姆病:皮肤损伤和关节炎的发展
  • 批准号:
    3154394
  • 财政年份:
    1985
  • 资助金额:
    $ 12.77万
  • 项目类别:
LYME DISEASE--DEVELOPMENT OF SKIN LESIONS AND ARTHRITIS
莱姆病——皮肤损伤和关节炎的发展
  • 批准号:
    3157450
  • 财政年份:
    1985
  • 资助金额:
    $ 12.77万
  • 项目类别:
LYME DISEASE--DEVELOPMENT OF SKIN LESIONS AND ARTHRITIS
莱姆病——皮肤损伤和关节炎的发展
  • 批准号:
    2079118
  • 财政年份:
    1985
  • 资助金额:
    $ 12.77万
  • 项目类别:
LYME DISEASE--DEVELOPMENT OF SKIN LESIONS AND ARTHRITIS
莱姆病——皮肤损伤和关节炎的发展
  • 批准号:
    3157451
  • 财政年份:
    1985
  • 资助金额:
    $ 12.77万
  • 项目类别:
LYME DISEASE--DEVELOPMENT OF SKIN LESIONS AND ARTHRITIS
莱姆病——皮肤损伤和关节炎的发展
  • 批准号:
    3157448
  • 财政年份:
    1985
  • 资助金额:
    $ 12.77万
  • 项目类别:
IMMUNOLOGICAL TOLERANCE AND AGING
免疫耐受和衰老
  • 批准号:
    3114125
  • 财政年份:
    1979
  • 资助金额:
    $ 12.77万
  • 项目类别:

相似海外基金

IMAGER: LYME DISEASE, BORRELIA BURGDOFERI & ARTHRITIS
成像仪:莱姆病、伯氏疏螺旋体
  • 批准号:
    7166351
  • 财政年份:
    2005
  • 资助金额:
    $ 12.77万
  • 项目类别:
XENOGEN IVIS 200 IMAGER: YERSENIA, LYME DISEASE, LYME ARTHRITIS,
XENOGEN IVIS 200 成像仪:耶尔森氏菌、莱姆病、莱姆关节炎、
  • 批准号:
    7166598
  • 财政年份:
    2005
  • 资助金额:
    $ 12.77万
  • 项目类别:
RHEUMATOID ARTHRITIS AND LYME DISEASE--T CELL RECEPTOR
类风湿性关节炎和莱姆病--T细胞受体
  • 批准号:
    3457027
  • 财政年份:
    1988
  • 资助金额:
    $ 12.77万
  • 项目类别:
RHEUMATOID ARTHRITIS AND LYME DISEASE--T CELL RECEPTOR
类风湿性关节炎和莱姆病--T细胞受体
  • 批准号:
    3457026
  • 财政年份:
    1988
  • 资助金额:
    $ 12.77万
  • 项目类别:
RHEUMATOID ARTHRITIS AND LYME DISEASE--T CELL RECEPTOR
类风湿性关节炎和莱姆病--T细胞受体
  • 批准号:
    3457024
  • 财政年份:
    1988
  • 资助金额:
    $ 12.77万
  • 项目类别:
RHEUMATOID ARTHRITIS AND LYME DISEASE--T CELL RECEPTOR
类风湿性关节炎和莱姆病--T细胞受体
  • 批准号:
    3457028
  • 财政年份:
    1988
  • 资助金额:
    $ 12.77万
  • 项目类别:
RHEUMATOID ARTHRITIS AND LYME DISEASE--T CELL RECEPTOR
类风湿性关节炎和莱姆病--T细胞受体
  • 批准号:
    3457025
  • 财政年份:
    1988
  • 资助金额:
    $ 12.77万
  • 项目类别:
LYME DISEASE: DEVELOPMENT OF SKIN LESIONS AND ARTHRITIS
莱姆病:皮肤损伤和关节炎的发展
  • 批准号:
    3157446
  • 财政年份:
    1985
  • 资助金额:
    $ 12.77万
  • 项目类别:
LYME DISEASE: DEVELOPMENT OF SKIN LESIONS AND ARTHRITIS
莱姆病:皮肤损伤和关节炎的发展
  • 批准号:
    3157449
  • 财政年份:
    1985
  • 资助金额:
    $ 12.77万
  • 项目类别:
LYME DISEASE: DEVELOPMENT OF SKIN LESIONS AND ARTHRITIS
莱姆病:皮肤损伤和关节炎的发展
  • 批准号:
    3154394
  • 财政年份:
    1985
  • 资助金额:
    $ 12.77万
  • 项目类别:
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