OSTEOPOROSIS IN MEXICAN AMERICANS AND NONHISPANIC WHITES

墨西哥裔美国人和非西班牙裔白人的骨质疏松症

• 批准号: 3160007
• 负责人: RICHARD L BAUER
• 金额: $ 14.56万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-04-01 至 1993-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3160007
• 关键词: Mexican Americans; bone density; bone imaging /visualization /scanning; caucasian American; disease /disorder model; disease /disorder proneness /risk; epidemiology; hip fractures; model design /development; musculoskeletal disorder diagnosis; osteoporosis; questionnaires

Mexican Americans, a large and growing minority population, have an incidence of hip fracture about 1/2 that of non-Hispanic whites. The reasons for this lower risk are unclear, but lower fracture risks in other ethnic groups, e.g., blacks, have been ascribed to greater bone mass. The bone mass of Mexican Americans and the relationship of bone mass to risk factors has never been examined. We propose to determine the bone mass of the hip and spine, sites of the most clinically important osteoporotic fractures, in a population based sample of 400 Mexican American and non-Hispanic white women. The study population to be examined has been followed since 1979 by the San Antonio Heart Study. Several risk factors for osteoporosis such as obesity, diet, exercise and medication use have been studied prospectively in this population. Additional risk factors for osteoporosis will be assessed by questionnaire and bone mass will be measured by dual photon absorptiometry. These data will be used to identify any differences in-bone mass between Mexican Americans and nonHispanic whites and to assess which risk factors might account for these differences. These data will also be used to develop predictive models relating risk factors to the bone mass of individuals. This information may yield useful information for clinicians and health care planners by indicating if and for whom bone mass measurements add any substantial information about fracture risk above that provided by clinical assessment alone.

墨西哥裔美国人是一个庞大且不断增长的少数民族， 髋部骨折的发生率约为非西班牙裔白人的1/2。 这种风险较低的原因尚不清楚，但下骨折 其他族裔群体的风险，例如，黑人被认为是 更大的骨量。 墨西哥裔美国人的骨量 骨量与危险因素的关系从未被研究过。 我们建议测定髋部和脊柱的骨量， 在临床上最重要的骨折中， 400名墨西哥裔美国人和非西班牙裔美国人 白色女人。 对要检查的研究人群进行了随访 自1979年以来，由圣安东尼奥心脏研究。 几个风险因素 对于骨质疏松症，如肥胖，饮食，运动和药物使用 在这一人群中进行了前瞻性研究。 额外 骨质疏松症的风险因素将通过问卷进行评估， 通过双光子吸收测定法测量骨量。 这些 数据将用于确定 墨西哥裔美国人和非西班牙裔白人，并评估 这些差异可能是由一些因素造成的。 这些数据还将用于开发预测模型， 影响个体骨量的危险因素。 这些信息 可能为临床医生和医疗保健提供有用的信息 通过指出骨量测量是否以及为谁增加 提供的任何关于骨折风险的实质性信息 仅通过临床评估。