DPA BONE MINERAL AND STRENGTH OF LUMBAR VERTEBRA

DPA 骨矿物质和腰椎强度

• 批准号: 3158190
• 负责人: CHARLES R WILSON
• 金额: $ 7.61万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-08-01 至 1988-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3158190
• 关键词: bone density; clinical biomedical equipment; computer assisted diagnosis; musculoskeletal disorder diagnosis; normal ossification; osteoporosis; scintillation cameras; spine

Osteoporosis is a considerable health problem which affects many of the nation's elderly and contributes significantly to the national health cost. The significance of theis work is in determining the relationship between the strength of the vertebra, its bone mineral mass and areal density measured using dual photon absorptiometric techniques. Excised vertebra will be mechanically loaded to failure to determine the compressive strength of the anterior portion of the vertebra. The bone mineral mass and areal density will be measured using the conventional DPA scanning technique and a new technique which employs a conventional gamma camera and computer for the detector and analysis system. The gamma camera significantly improves resolution and data collection efficiency compared to the current DPA technique, and measurements are now possible in the lateral spine. Measurement of the lateral spine is advantageous in that it provides a direct measurement of the load bearing anterior portion of the vertebra. The objective of this study is to determine whether a measurement of areal density restricted to the vertebral body is superior for estimating the strength than the integrated measurement obtained in the frontal projection in current DPA systems. Successful validation of the gamma camera and computer as a superior system for meaningful measurement in the osteoporotic patient will allow accurate and sensitive bone densitometry to be performed in a broad base of existing clinical installations.

骨质疏松症是一个严重的健康问题，影响着许多人 为国民健康做出了重大贡献 成本。 这项工作的意义在于确定关系 椎骨强度、骨矿物质质量和面积之间的关系 使用双光子吸收技术测量密度。 切除的 椎骨将被机械加载至无法确定 椎骨前部的抗压强度。 骨头 矿物质量和面密度将使用传统的 DPA 进行测量 扫描技术和采用传统伽玛的新技术 用于检测器和分析系统的摄像机和计算机。 伽玛相机 相比之下，分辨率和数据采集效率显着提高 到当前的 DPA 技术，现在可以在 侧脊柱。 测量脊柱侧向的优点在于 提供对前部承重的直接测量 椎骨。 本研究的目的是确定是否 仅限于椎体的面密度测量效果更佳 用于估计强度比在中获得的综合测量 当前 DPA 系统中的正面投影。 成功验证 伽玛相机和计算机作为有意义测量的高级系统 在骨质疏松症患者中将允许准确和敏感的骨 密度测定将在现有临床的广泛基础上进行 装置。

项目成果

In vitro biomechanical study of female geriatric cervical vertebral bodies.

女性老年颈椎体的体外生物力学研究。

• DOI: 10.1016/0141-5425(90)90127-9
• 发表时间: 1990
• 期刊: Journal of biomedical engineering
• 作者: Yoganandan,N;Pintar,F;Wilson,CR;SancesJr,A
• 通讯作者: SancesJr,A