ERYTHROID DIFFERENTIATION IN FRIEND LEUKEMIA CELLS

友人白血病细胞中的红细胞分化

• 批准号: 3164737
• 负责人: David Housman
• 金额: $ 18.2万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-05-01 至 1988-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3164737
• 关键词: Friend leukemia; cell differentiation; cell population study; cellular oncology; chromatin; clone cells; erythrocytes; erythroleukemia; gel electrophoresis; gene expression; genetic manipulation; genetic transcription; messenger RNA; molecular cloning; molecular oncology; neoplasm /cancer genetics; nucleic acid metabolism; nucleic acid sequence; ribosomal RNA

Three basic lines of investigation pertaining to the control of erythroid differentiation of murine erythroleukemia cells will be investigated. The molecular processes that are responsible for the commitment of these cells to terminal erythroid differentiation will be studied. The relationship between globin mRNA synthesis and commitment will be analyzed. The control of genes expressed during the terminal phase of the program will also be studied. (M)

与红细胞控制有关的三条基本研究路线 将研究鼠红白血病细胞的分化。 的 负责这些细胞定向的分子过程 终末红细胞分化将被研究。 的关系 将分析珠蛋白mRNA合成和定型之间的关系。 控制 在该计划的最后阶段表达的基因也将被 研究了 （百万）