TUMOR IMAGING WITH RADIOLABELED MONOCLONAL ANTIBODY
使用放射性标记单克隆抗体进行肿瘤成像
基本信息
- 批准号:3168807
- 负责人:
- 金额:$ 24.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1981
- 资助国家:美国
- 起止时间:1981-05-01 至 1992-11-30
- 项目状态:已结题
- 来源:
- 关键词:athymic mouse beta glucosidases human subject hybridomas image processing lymph node neoplasm melanoma metastasis monoclonal antibody neoplasm /cancer immunotherapy neoplasm /cancer radiation therapy neoplasm /cancer radionuclide diagnosis peptidases radionuclide imaging /scanning radiotracer technetium tumor antigens tyramine
项目摘要
This grant combines an integrated set of laboratory science and
clinical investigations specifically focused on improving the
ability to diagnostically image and potentially treat human cancer
using radiolabeled monoclonal antibodies. In Aim 1 we will develop
improved methods of antibody radioiodination using an iodinated
tyramine-cellobiose (TCB) adduct, designed to produce increased
retention of radioiodine in tumors. Labeling methods will be
optimized for yields and preservation of immunoreactivity and
products will be tested in tumor cell suspensions and in tumored
mice. In Aim 2 we will attempt immunospecific lymphoscintigraphy
of tumored nodes in patients with metastatic melanoma. We have
demonstrated non-specific uptake of antibody in tumored nodes; this
will be blocked with subcutaneous doses of cold irrelevant antibody
prior to simultaneous injection of I-131 specific and I-125 non-
specific antibody. After I-131 imaging excised nodes will be
analyzed by counting and dual isotope autoradiography. In Aim 3
we will extend our work on antibody imaging of documented melanoma
and eventually cancers of the lung and breast. Using diagnostic
doses of I-131 labeled antibody we will carefully measure
biodistribution and tumor labeling and make estimates of internal
radiation absorbed doses. We will determine if the quality of
imaging and tumor deposition of antibody radiolabeled by the para-
iodophenyl and tyramine-cellobiose methods is improved compared to
chloramine-T labeled antibody. In Aim 4 we will select patients
who show good tumor uptake with I-131 antibody and treat them with
single high doses of I-131 antibody. To circumvent bone marrow
damage with this treatment, patients will have marrow stored prior
to therapy and reinfused afterward.
这项拨款结合了一套完整的实验室科学和
项目成果
期刊论文数量(0)
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{{ truncateString('WIL B NELP', 18)}}的其他基金
TUMOR IMAGING WITH RADIOLABELLED MONOCLONAL ANTIBODY
使用放射性标记单克隆抗体进行肿瘤成像
- 批准号:
3168804 - 财政年份:1984
- 资助金额:
$ 24.28万 - 项目类别:
TUMOR IMAGING WITH RADIOLABELLED MONOCLONAL ANTIBODY
使用放射性标记单克隆抗体进行肿瘤成像
- 批准号:
3168803 - 财政年份:1984
- 资助金额:
$ 24.28万 - 项目类别:
TUMOR IMAGING WITH RADIOLABELLED MONOCLONAL ANTIBODY
使用放射性标记单克隆抗体进行肿瘤成像
- 批准号:
3168802 - 财政年份:1984
- 资助金额:
$ 24.28万 - 项目类别:
TUMOR IMAGING WITH RADIOLABELED MONOCLONAL ANTIBODY
使用放射性标记单克隆抗体进行肿瘤成像
- 批准号:
3168808 - 财政年份:1981
- 资助金额:
$ 24.28万 - 项目类别:
TUMOR IMAGING WITH RADIOLABELED MONOCLONAL ANTIBODY
使用放射性标记单克隆抗体进行肿瘤成像
- 批准号:
3168806 - 财政年份:1981
- 资助金额:
$ 24.28万 - 项目类别:
TUMOR IMAGING WITH RADIOLABELED MONOCLONAL ANTIBODY
使用放射性标记单克隆抗体进行肿瘤成像
- 批准号:
3168805 - 财政年份:1981
- 资助金额:
$ 24.28万 - 项目类别:
TUMOR IMAGING WITH RADIOLABELLED MONOCLONAL ANTIBODY
使用放射性标记单克隆抗体进行肿瘤成像
- 批准号:
3168801 - 财政年份:1981
- 资助金额:
$ 24.28万 - 项目类别:
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