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ERYTHROID DIFFERENTIATION IN FRIEND LEUKEMIA CELLS

ERYTHROID DIFFERENTIATION IN FRIEND LEUKEMIA CELLS
友人白血病细胞中的红细胞分化
批准号：
3164735
负责人：
David Housman
金额：
$17.15万
依托单位：
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
1978
资助国家：
美国
项目状态：
已结题
起止时间：
1978-05-01 至 1988-04-30
来源：
https://reporter.nih.gov/project-details/3164735
关键词：
Friend leukemia cell differentiation cell population study cellular oncology chromatin clone cells erythrocytes erythroleukemia gel electrophoresis gene expression genetic manipulation genetic transcription messenger RNA molecular cloning molecular oncology neoplasm /cancer genetics nucleic acid metabolism nucleic acid sequence ribosomal RNA

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Three basic lines of investigation pertaining to the control of erythroid differentiation of murine erythroleukemia cells will be investigated. The molecular processes that are responsible for the commitment of these cells to terminal erythroid differentiation will be studied. The relationship between globin mRNA synthesis and commitment will be analyzed. The control of genes expressed during the terminal phase of the program will also be studied. (M)
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