SYNTHESIS OF BRIDGED POLYCYCLIC ANTITUMOR AGENTS

桥联多环抗肿瘤剂的合成

• 批准号: 3165064
• 负责人: ANDREW S KENDE
• 金额: $ 12.49万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-06-30 至 1987-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3165064
• 关键词: diterpenes; drug design /synthesis /production; heterocyclic compounds; lactones; podophyllin; quinones; stereochemistry

This project seeks to achieve the first laboratory synthesis of taxane diterpenes. During this work the synthetic utility of condensations between enolates and haloolefins to yield dichlorovinyl and ethinyl derivatives of ketones and esters has been demonstrated. Related studies recently completed include the total synthesis of streptonigrin and the first practical total synthesis of 4'-O-demethyl-4-epipodophyllotoxin.

该项目旨在实现紫杉烷的首次实验室合成