Transport mechanism of a multidrug transporter from Vibrio cholerae

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We live in a time in which drug resistance has become a global threat to health care and in which concerns about the lack of effective antimicrobial drugs are communicated with increasing frequency. One very powerful mechanism of drug resistance in microorganisms is based on the transport of the drugs out of the cell by pump proteins that can recognise an extraordinarily broad range of antibiotics and disinfectants. In this project, we ask a few simple questions about these proteins: how do they bind substrates and how do they use cell's energy to pump? Answers to these questions will allow us to generate inhibitors of these pump proteins and new antibiotics that can bypass drug pumping.