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MODULATION OF THE TUMORIGENICITY OF TRANSFORMED CELLS

MODULATION OF THE TUMORIGENICITY OF TRANSFORMED CELLS
转化细胞致瘤性的调节
批准号：
3166810
负责人：
Mary K. Katherine Howett
金额：
$12.57万
依托单位：
PENNSYLVANIA STATE UNIV HERSHEY MED CTR
依托单位国家：
美国
项目类别：
财政年份：
1979
资助国家：
美国
项目状态：
已结题
起止时间：
1979-04-01 至 1991-01-31
来源：
https://reporter.nih.gov/project-details/3166810
关键词：
DNA virus Herpes simplex disease Papillomavirus athymic mouse cellular oncology cervix neoplasms complementary DNA condyloma acuminatum disease /disorder model gene expression genetic library genetic transcription herpes simplex virus 2 human tissue latent virus infection messenger RNA molecular cloning molecular oncology mutagens natural gene amplification neoplastic cell oncogenes oncogenic virus radiotracer simian virus 40 tissue /cell culture tissue mosaicism viral carcinogenesis virus antigen virus genetics virus related neoplasm /cancer

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中文摘要
翻译
越来越多的证据表明，乳头瘤病毒（HPV）与 与一些人类癌症有关。 在本提案中，我们将 实验性地产生HPV感染/转化的人体组织， 在基因表达水平上被激活。 激活或 扩增的基因将在构建的cDNA文库中鉴定 从组织的mRNA库中分离出来。 将被检测的基因 包括病毒特异性和细胞基因。 实验 感染/转化的组织也将与正常组织进行比较 诱变敏感性的当量。
英文摘要
Evidence is mounting that papillomaviruses (HPV) are associated with a number of human cancers. In this proposal, we will experimentally generate HPV-infected/transformed human tissues that are activated at the level of gene expression. Activated or amplified genes will be identified in cDNA libraries constructed from the mRNA pool of the tissues. Genes that will be examined include virus specific and cellular genes. Experimentally infected/transformed tissues will also be compared with normal equivalents for susceptibility to mutagenesis.
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