US partnering on the use of neutron scattering to study aggregation in therapeutic proteins during manufacture and storage

美国合作利用中子散射来研究治疗性蛋白质在制造和储存过程中的聚集

• 批准号: BB/K021354/1
• 负责人: Paul Dalby
• 金额: $ 5.5万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FK021354%2F1
• 关键词: US; partnering; use; neutron; scattering

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前，GtR 中尚未提供所有资助研究的摘要。这通常是因为在提交提案时不需要摘要，但可能是因为它包含个人详细信息等敏感信息。

项目成果

In situ neutron scattering of antibody adsorption during protein A chromatography.

Protein A 层析过程中抗体吸附的原位中子散射。

• DOI: 10.1016/j.chroma.2019.460842
• 发表时间: 2020
• 期刊: Journal of chromatography. A
• 作者: Papachristodoulou M

Neutron reflectivity measurement of protein A-antibody complex at the solid-liquid interface.

• DOI: 10.1016/j.chroma.2017.03.084
• 发表时间: 2017-05-26
• 期刊: Journal of chromatography. A
• 作者: Mazzer AR;Clifton LA;Perevozchikova T;Butler PD;Roberts CJ;Bracewell DG
• 通讯作者: Bracewell DG

An Expanded Conformation of an Antibody Fab Region by X-Ray Scattering, Molecular Dynamics, and smFRET Identifies an Aggregation Mechanism

• DOI: 10.1016/j.jmb.2019.02.009
• 发表时间: 2019-03-29
• 期刊: JOURNAL OF MOLECULAR BIOLOGY
• 影响因子: 5.6
• 作者: Codina, Nuria;Hilton, David;Dalby, Paul A.
• 通讯作者: Dalby, Paul A.

Protein A chromatography increases monoclonal antibody aggregation rate during subsequent low pH virus inactivation hold.

• DOI: 10.1016/j.chroma.2015.08.068
• 发表时间: 2015-10-09
• 期刊: Journal of chromatography. A
• 作者: Mazzer AR;Perraud X;Halley J;O'Hara J;Bracewell DG
• 通讯作者: Bracewell DG