课题基金 / 基金详情

TRANSFORMATION BY ABELSON MURINE LEUKEMIA VIRUS

TRANSFORMATION BY ABELSON MURINE LEUKEMIA VIRUS
阿贝尔森鼠白血病病毒的转化
批准号：
3167662
负责人：
OWEN N. WITTE
金额：
$14.95万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1980
资助国家：
美国
项目状态：
已结题
起止时间：
1980-05-01 至 1991-04-30
来源：
https://reporter.nih.gov/project-details/3167662
关键词：
Abelson leukemia virus disease /disorder model gene expression genetic manipulation genetic regulation helper virus myelogenous leukemia oncogenic virus radiotracer serology /serodiagnosis surface antigens temperature sensitive mutant tissue /cell culture viral leukemogenesis virus RNA virus genetics

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英文摘要
This proposal will investigate the molecular mechanisms used by the abl oncogene in its normal and abnormal growth regulation. Comparison of the structures, regulation, hematopoietic transformation activities, and tyrosine kinase enzymatic properties of the murine cellular, and viral forms of the abl gene as well as the translocation derived form of the abl gene found in Chronic Myelogenous Leukemia cells will be performed. Emphasis will be placed on establishing transformed cell models for murine stem cell populations under the regulation of abl or other oncogenes in concert with improved culture techniques. These studies should aid our understanding of the mechanisms of oncogenesis and hematopoietic development.
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