CHOLINE DEFICIENCY, OVAL CELLS AND HEPATOCARCINOGENESIS
胆碱缺乏、卵圆细胞和肝癌发生
基本信息
- 批准号:3166148
- 负责人:
- 金额:$ 2.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1978
- 资助国家:美国
- 起止时间:1978-04-01 至 1986-11-30
- 项目状态:已结题
- 来源:
- 关键词:alpha fetoprotein cell population study chemical carcinogenesis electron microscopy histochemistry /cytochemistry immunofluorescence technique liver cells liver neoplasms neoplasm /cancer immunology nutrition aspect of cancer nutrition related tag pathogenic diet preneoplastic state radioimmunoassay radiotracer tissue /cell culture tissue /cell preparation tumor promoters ultracentrifugation
项目摘要
The research proposed in this application is designed to study two aspects of
chemical hepatocarcinogenesis: 1) the influence of a dietary deficiency of a
single nutritive factor, choline, on tumor induction; and, 2) the nature and
functional properties of so-called oval cells. Feeding a diet devoid of choline
to rats has been shown to promote the induction of preneoplastic lesions, as
well as of hepatocellular carcinomas, by several known chemical carcinogens.
Studies are proposed aimed at investigating possible mechanism(s) whereby the
diet acts as a promoter of liver carcinogenesis. Mechanisms to be considered
are: 1) stimulation of hepatocyte replication; 2) diet and carcinogen-induced
changes in the properties of hepatocyte membranes; and, 3) transmethylation
reactions involving methylation of hepatocyte macromolecules. The influence of
the diet on initiation of liver carcinogenesis will also be investigated. In
recent years, a renewed interest has developed about the possibility that bile
duct(ular) cells, beside hepatocytes, may also be target cells of chemical
hepatocarcinogens, and progenitors, in certain instances, of hepatocellular
carcinomas as well as of cholangiocarcinomas. Proliferation of bile duct(ular)
cells, with emergence of so-called oval cells, is a common, early event
occurring in the liver of rats exposed to chemial carcinogens. Studies are
proposed aimed at achieving the isolation of homogeneous preparations of oval
cells from the liver of carcinogen-treated rats; at investigating some of the
metabolic and biologic properties of these cells; and, at probing whether these
cells do indeed play any role in the genesis of epithelial liver tumors.
本应用提出的研究主要从两个方面进行研究
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
BENITO LOMBARDI其他文献
BENITO LOMBARDI的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('BENITO LOMBARDI', 18)}}的其他基金
GROWTH MODULATORY AND PROMOTERS OF LIVER CANCER II
肝癌生长调节剂和促进剂 II
- 批准号:
3173674 - 财政年份:1984
- 资助金额:
$ 2.15万 - 项目类别:
GROWTH MODULATORY AND PROMOTERS OF LIVER CANCER II
肝癌生长调节剂和促进剂 II
- 批准号:
3173675 - 财政年份:1984
- 资助金额:
$ 2.15万 - 项目类别:
CHOLINE DEFICIENCY, OVAL CELLS AND HEPATOCARCINOGENESIS
胆碱缺乏、卵圆细胞和肝癌发生
- 批准号:
3166150 - 财政年份:1978
- 资助金额:
$ 2.15万 - 项目类别: