CHOLINE DEFICIENCY, OVAL CELLS AND HEPATOCARCINOGENESIS

胆碱缺乏、卵圆细胞和肝癌发生

基本信息

  • 批准号:
    3166148
  • 负责人:
  • 金额:
    $ 2.15万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1978
  • 资助国家:
    美国
  • 起止时间:
    1978-04-01 至 1986-11-30
  • 项目状态:
    已结题

项目摘要

The research proposed in this application is designed to study two aspects of chemical hepatocarcinogenesis: 1) the influence of a dietary deficiency of a single nutritive factor, choline, on tumor induction; and, 2) the nature and functional properties of so-called oval cells. Feeding a diet devoid of choline to rats has been shown to promote the induction of preneoplastic lesions, as well as of hepatocellular carcinomas, by several known chemical carcinogens. Studies are proposed aimed at investigating possible mechanism(s) whereby the diet acts as a promoter of liver carcinogenesis. Mechanisms to be considered are: 1) stimulation of hepatocyte replication; 2) diet and carcinogen-induced changes in the properties of hepatocyte membranes; and, 3) transmethylation reactions involving methylation of hepatocyte macromolecules. The influence of the diet on initiation of liver carcinogenesis will also be investigated. In recent years, a renewed interest has developed about the possibility that bile duct(ular) cells, beside hepatocytes, may also be target cells of chemical hepatocarcinogens, and progenitors, in certain instances, of hepatocellular carcinomas as well as of cholangiocarcinomas. Proliferation of bile duct(ular) cells, with emergence of so-called oval cells, is a common, early event occurring in the liver of rats exposed to chemial carcinogens. Studies are proposed aimed at achieving the isolation of homogeneous preparations of oval cells from the liver of carcinogen-treated rats; at investigating some of the metabolic and biologic properties of these cells; and, at probing whether these cells do indeed play any role in the genesis of epithelial liver tumors.
本应用提出的研究主要从两个方面进行研究

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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BENITO LOMBARDI其他文献

BENITO LOMBARDI的其他文献

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{{ truncateString('BENITO LOMBARDI', 18)}}的其他基金

GROWTH MODULATORY AND PROMOTERS OF LIVER CANCER II
肝癌生长调节剂和促进剂 II
  • 批准号:
    3173674
  • 财政年份:
    1984
  • 资助金额:
    $ 2.15万
  • 项目类别:
GROWTH MODULATORY AND PROMOTERS OF LIVER CANCER II
肝癌生长调节剂和促进剂 II
  • 批准号:
    3173675
  • 财政年份:
    1984
  • 资助金额:
    $ 2.15万
  • 项目类别:
CHOLINE DEFICIENCY AND HEPATOCARCINOGENESIS
胆碱缺乏与肝癌发生
  • 批准号:
    3166147
  • 财政年份:
    1978
  • 资助金额:
    $ 2.15万
  • 项目类别:
CHOLINE DEFICIENCY AND HEPATOCARCINOGENESIS
胆碱缺乏与肝癌发生
  • 批准号:
    3166146
  • 财政年份:
    1978
  • 资助金额:
    $ 2.15万
  • 项目类别:
CHOLINE DEFICIENCY AND HEPATOCARCINOGENESIS
胆碱缺乏与肝癌发生
  • 批准号:
    2087175
  • 财政年份:
    1978
  • 资助金额:
    $ 2.15万
  • 项目类别:
CHOLINE DEFICIENCY AND HEPATOCARCINOGENSIS
胆碱缺乏与肝癌
  • 批准号:
    3166155
  • 财政年份:
    1978
  • 资助金额:
    $ 2.15万
  • 项目类别:
CHOLINE DEFICIENCY, OVAL CELLS AND HEPATOCARCINOGENESIS
胆碱缺乏、卵圆细胞和肝癌发生
  • 批准号:
    3166150
  • 财政年份:
    1978
  • 资助金额:
    $ 2.15万
  • 项目类别:
CHOLINE DEFICIENCY AND HEPATOCARCINOGENESIS
胆碱缺乏与肝癌发生
  • 批准号:
    3166154
  • 财政年份:
    1978
  • 资助金额:
    $ 2.15万
  • 项目类别:
CHOLINE DEFICIENCY AND HEPATOCARCINOGENESIS
胆碱缺乏与肝癌发生
  • 批准号:
    3166153
  • 财政年份:
    1978
  • 资助金额:
    $ 2.15万
  • 项目类别:
CHOLINE DEFICIENCY AND HEPATOCARCINOGENESIS
胆碱缺乏与肝癌发生
  • 批准号:
    3166151
  • 财政年份:
    1978
  • 资助金额:
    $ 2.15万
  • 项目类别:
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