MINOR ALLOANTIGENS IN CLINICAL GRAFT VS. HOST REACTION

临床移植物与非移植物中的次要同种异体抗原

• 批准号: 3171580
• 负责人: WILLIAM L. ELKINS
• 金额: $ 10.87万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-04-01 至 1986-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3171580
• 关键词: bone marrow transplantation; family; flow cytometry; graft versus host disease; homologous transplantation; human subject; leukemia; minor histocompatibility loci; tissue donors; tumor antigens

Clinical bone marrow transplantation between HLA-matched siblings is often complicated by the development of graft-versus-host (GVH) disease. GVH reactions result from the recognition of foreign minor histocompatibility antigens of the host by T lymphocytes in the bone marrow graft. Little is known about these antigens because there have been no identifying reagents for this study. We have successfully generated cytotoxic T-cell lines from the blood of recipients of HLA-matched marrow grafts. These effectors demonstrate specificity for factors inherited within the family that segregate independently of HLA and are thus identified as minor alloantigens. Such CTL have been generated even from cases in which there was no evident GVHD, nevertheless they may identify minor antigens capable of triggering GVH reactions. Current studies are directed at identifying these minor antigens in the general population. We are seeking antigens that may be of special importance in BMT by virtue of modest frequency, just as those of the ABO system are important in blood transfusion. (TT)

临床骨髓移植在hla匹配的兄弟姐妹之间经常是