CHOLECYSTECTOMY AND SUBSITE-SPECIFIC LARGE BOWEL CANCER

胆囊切除术和亚部位特异性大肠癌

• 批准号: 3171770
• 负责人: WILLIAM M HAENSZEL
• 金额: $ 8.47万
• 依托单位: ILLINOIS CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-02-01 至 1986-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3171770
• 关键词: cancer information system; cancer registry /resource; cancer risk; case history; cholecystectomy; clinical chemistry; gallbladder disorder; gender difference; histopathology; human age group; interview; neoplasm /cancer diagnosis; patient /disease registry; rectum neoplasms

An epidemiologic case-control study is proposed to determine if cholecystectomy is a risk factor for right-side colon cancer, left-side colon cancer, or rectal cancer. The study, which will be conducted at the Illinois Cancer Council, is designed to allow investigation of this relationship among males, females, and age-specific subgroups and by duration of exposure since cholecystectomy. Each of the three case groups will be compared to a single control series consisting of the spouses of the identified patients. Comparisons will be made of male cases with the spouses of the female cases and female cases with the spouses of the male cases. The gastrointestinal surgical history will be ascertained for all study subjects so that the presence or absence of a history of cholecystectomy can be noted. Cholecystectomy history will be obtained through telephone interviews and subsequently validated from operative and pathology reports at time of this surgery. Cholecystectomy history for the large bowel cancer patients will also be abstracted from hospital records at time of cancer diagnosis and attempts will be made to confirm the status of the gallblader through operative reports, oral or ultrasonic cholecystography and physical examinations. If the results of this investigation are positive, a larger study involving multiple centers is sugested to investigate the effects of gallbladder diesase, with and without cholecystectomy, on the risk for subsite-specific large bowel cancer. In addition, a clinical cross-sectional study involving large bowel cancer patients and controls, with and without cholecystectomy, might be justified. Such a study would include assays of fecal mutagens, fecal bile acid and cholesterol metabolites and intestinal bacteria, as well as mutagenic testing of subsite-specific large bowel epithelium. The relationship between biliary metabolism and large bowel cancer is unclear, and therefore the results from the current and potential, subsequent investigations may increase the understanding of this relationship. Thus, knowledge of the etiology of large bowel cancer may be increased.

一项流行病学病例对照研究被提出来确定， 胆囊切除术是右半结肠癌的危险因素， 结肠癌或直肠癌。 这项研究将在 伊利诺伊州癌症理事会，旨在允许调查这一点 男性、女性和特定年龄亚组之间的关系， 自胆囊切除术后的暴露持续时间。 三个病例组 将与由以下配偶组成的单一对照系列进行比较： 确认的患者。 将男性病例与 女性的配偶和女性与男性的配偶 例 将对所有患者确定胃肠道手术史 研究对象，以便有无病史， 胆囊切除术。 将获得霍乱病史 通过电话访谈，随后从业务部门和 手术时的病理报告 霍乱史 大肠癌患者也将从医院记录中提取 在癌症诊断时，将尝试确认状态 通过手术报告，口腔或超声检查 胆囊造影和体格检查。 如果这件事的结果 研究是积极的，一项涉及多个中心的更大规模的研究， 建议研究胆囊疾病的影响， 不进行胆囊切除术， 癌 此外，一项涉及大样本的临床横断面研究 肠癌患者和对照组，有或没有胆囊切除术，可能 是有道理的 这样的研究将包括粪便诱变剂、粪便突变剂和粪便突变剂的测定。 胆汁酸和胆固醇代谢产物和肠道细菌，以及 亚单位特异性大肠上皮的诱变试验。 的 胆汁代谢和大肠癌之间的关系尚不清楚， 因此，电流和电势的结果， 调查可以增加对这种关系的了解。 因此，在本发明中， 可增加对大肠癌病因学的认识。

项目成果

Selection of neighborhood controls: logistics and fieldwork.

邻里控制的选择：后勤和现场工作。

• DOI: 10.1016/0021-9681(84)90145-0
• 发表时间: 1984
• 期刊: Journal of chronic diseases
• 作者: Vernick,LJ;Vernick,SL;Kuller,LH
• 通讯作者: Kuller,LH