SPECTROSCOPIC AND PHOTOPHYSICAL CHARACTERIZATION

光谱和光物理特征

• 批准号: 3171816
• 负责人: EDWARD LIM
• 金额: $ 7.63万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-02-01 至 1986-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3171816
• 关键词: Raman spectrometry; chemical structure function; ferriheme; neoplasm /cancer diagnosis; neoplasm /cancer pharmacology; neoplasm /cancer photoradiation therapy; porphyrins; spectrometry

Hematoporphyrin derivatives (HPD) is a complex mixture of porphyrins which has proved useful in cancer therapy and diagnosis. The primary goal of the proposed research is to identify, anc characterize, the tumor-localizing component(s) of HPD for the purpose of understanding the mode of the drug localization and the mechanism of the tumor-killing. Site-selection spectroscopy and resonance Raman spectroscopy, both based on tunable dye laser systems, will be used for the purpose. We also propose to compare photophysical properties (quantum yield of triplet formation, triplet state lifetime; and quantum yield and lifetime of fluorescence) of various porphyrins with their photosensitization efficiencies to deduce the factors that determine the efficiency of photodynamic action. These measurements are of fundamental importance to the improved therapeutic use of HPD and to the design of more efficient and less harmful drugs which could render photoradiation therapy a very powerful method of treating cancerous tissues.

血卟啉衍生物（HPD）是卟啉的复杂混合物， 已经证明在癌症治疗和诊断中是有用的。 的首要目标 建议的研究是识别和表征肿瘤定位， HPD的组分，以了解药物的模式 定位和杀伤肿瘤的机制。 选址 光谱和共振拉曼光谱，两者都基于可调谐染料 激光系统将用于此目的。 我们还建议比较 物理性质（三重态形成的量子产率，三重态 寿命;以及各种荧光的量子产率和寿命） 卟啉类化合物及其光敏化效率， 决定了光动力作用的效率。 这些测量 对于改善HPD的治疗用途和 设计出更有效、危害更小的药物， 光辐射疗法是治疗癌组织的一种非常有效的方法。