SPECTROSCOPIC AND PHOTOPHYSICAL CHARACTERIZATION

血卟啉衍生物(HPD)是一种复杂的卟啉混合物，它 已被证明在癌症治疗和诊断中很有用。的主要目标是 建议的研究是确定，ANC特征，肿瘤的定位 血凝素成分(S)，以了解药物的模式 肿瘤的定位和杀瘤机制。选址 光谱和共振拉曼光谱，均基于可调谐染料 激光系统，将用于这一目的。我们还建议将 光物理特性(三线态的量子产额、三线态 寿命；以及量子产额和荧光寿命) 用卟啉类化合物的光敏化效率推断影响因素 它们决定了光动力作用的效率。这些测量结果 对于改善HPD的治疗用途和 设计出更有效、危害更小的药物，从而使 光放射疗法是治疗癌症组织的一种非常有效的方法.

Hematoporphyrin derivatives (HPD) is a complex mixture of porphyrins which has proved useful in cancer therapy and diagnosis. The primary goal of the proposed research is to identify, anc characterize, the tumor-localizing component(s) of HPD for the purpose of understanding the mode of the drug localization and the mechanism of the tumor-killing. Site-selection spectroscopy and resonance Raman spectroscopy, both based on tunable dye laser systems, will be used for the purpose. We also propose to compare photophysical properties (quantum yield of triplet formation, triplet state lifetime; and quantum yield and lifetime of fluorescence) of various porphyrins with their photosensitization efficiencies to deduce the factors that determine the efficiency of photodynamic action. These measurements are of fundamental importance to the improved therapeutic use of HPD and to the design of more efficient and less harmful drugs which could render photoradiation therapy a very powerful method of treating cancerous tissues.