SV40-INDUCED CHANGES IN GROWTH REGULATION IN HOST CELLS

SV40 引起宿主细胞生长调节的变化

基本信息

  • 批准号:
    3174873
  • 负责人:
  • 金额:
    $ 13.28万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1984
  • 资助国家:
    美国
  • 起止时间:
    1984-03-01 至 1990-08-31
  • 项目状态:
    已结题

项目摘要

The objective of this research is to understand the mechanism(s) by which S-phase specific genes are regulated in normal and SV40- infected cells. Since the expression of these genes is correlated with the growth state of the cell, it is hoped that an understand of their regulation will contribute to an understanding of the control of cell growth in normal and virus-infected cells. This understanding will in turn be important to the study of oncogenic transformation, since one of the properties of transformed cells is that they fail to regulate their growth in a normal way. The approach taken to investigating the regulation of S-phase specific genes will be a molecular one, using the thymidine kinase (TK) gene as a model system. TK expression is regulated during the cell cycle, being low in G0 and G1 phase cells, and increasing as the cells enter S phase. Both genomic and cDNA TK clones will be used to construct a series of mutant and hybrid TK genes. These altered genes will then be transfected into tissue culture cells, and the regulation of their expression will be examined. Using these techniques, the following questions concerning TK regulation will be addressed: 1) At what levels does regulation of the gene occur (transcriptional/post-transcriptional, etc.)? 2) What TK DNA sequences are responsible for this regulation? 3) What is the role of viral proteins in inducing the TK gene? 4) What cellular factor or factors are involved in inducing the TK gene?
本研究的目的是了解其机制。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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SUSAN E CONRAD其他文献

SUSAN E CONRAD的其他文献

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{{ truncateString('SUSAN E CONRAD', 18)}}的其他基金

THE USE OF VIDEO MICROSCOPY IN TYPE 1 DIABETES MELLITUS
视频显微镜在 1 型糖尿病中的应用
  • 批准号:
    7204955
  • 财政年份:
    2005
  • 资助金额:
    $ 13.28万
  • 项目类别:
ESTROGEN REGULATION OF BREAST CANCER CELL PROLIFERATION
雌激素对乳腺癌细胞增殖的调节
  • 批准号:
    6173172
  • 财政年份:
    1998
  • 资助金额:
    $ 13.28万
  • 项目类别:
ESTROGEN REGULATION OF BREAST CANCER CELL PROLIFERATION
雌激素对乳腺癌细胞增殖的调节
  • 批准号:
    6376616
  • 财政年份:
    1998
  • 资助金额:
    $ 13.28万
  • 项目类别:
ESTROGEN REGULATION OF BREAST CANCER CELL PROLIFERATION
雌激素对乳腺癌细胞增殖的调节
  • 批准号:
    2896302
  • 财政年份:
    1998
  • 资助金额:
    $ 13.28万
  • 项目类别:
ESTROGEN REGULATION OF BREAST CANCER CELL PROLIFERATION
雌激素对乳腺癌细胞增殖的调节
  • 批准号:
    2692078
  • 财政年份:
    1998
  • 资助金额:
    $ 13.28万
  • 项目类别:
SV40-INDUCED CHANGES OF GROWTH REGULATION IN HOST CELLS
SV40 诱导宿主细胞生长调节的变化
  • 批准号:
    3174871
  • 财政年份:
    1984
  • 资助金额:
    $ 13.28万
  • 项目类别:
SV40-INDUCED CHANGES IN GROWTH REGULATION IN HOST CELLS
SV40 引起宿主细胞生长调节的变化
  • 批准号:
    3174874
  • 财政年份:
    1984
  • 资助金额:
    $ 13.28万
  • 项目类别:
SV40-INDUCED CHANGES IN GROWTH REGULATION IN HOST CELLS
SV40 引起宿主细胞生长调节的变化
  • 批准号:
    3174867
  • 财政年份:
    1984
  • 资助金额:
    $ 13.28万
  • 项目类别:
SV40-INDUCED CHANGES OF GROWTH REGULATION IN HOST CELLS
SV40 诱导宿主细胞生长调节的变化
  • 批准号:
    3174872
  • 财政年份:
    1984
  • 资助金额:
    $ 13.28万
  • 项目类别:
SV40 INDUCTION OF CELLULAR ONCOGENES
SV40 诱导细胞癌基因
  • 批准号:
    3931981
  • 财政年份:
  • 资助金额:
    $ 13.28万
  • 项目类别:

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