ANIMAL STUDIES WITH A DEVICE FOR FOCUSED DEEP HEATING

使用集中深度加热装置进行的动物研究

• 批准号: 3174266
• 负责人: ARTHUR W BODDIE
• 金额: $ 6.56万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-12-01 至 1986-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3174266
• 关键词: X ray; abdomen; anesthesia; central nervous system; clinical biomedical equipment; human therapy evaluation; neoplasm /cancer radiation therapy; neoplasm /cancer thermotherapy; pelvis; thorax

A new hybrid radiofrequency applicator consisting of inductive, capacitive, and grounded elements whose phase and/or spatial orientation are variable has previously been shown to be capable of precisely focused heating at depths of 10cm or more in phantom models of homogeneous dielectric. This device will be utilized to study the practicality and/or the safety of precisely focused deep heating in minipig carcasses complex phantoms and living anesthetized minipigs. Focal heating will be attempted in anatomic sites in the abdomen, pelvis, thorax, and CNS selected because of current difficulties in applying hyperthermia in tumors in these locations. Initially, power deposition patterns in minipig carcasses and complex phantoms of minipig carcasses at thermal equilibrium will be monitored using invasive non-field perturbing probes during heating. Subsequently, two dimensional heating patterns at the surface and in various planes through transected phantoms will be determined using thermally sensitive liquid crystal paper and/or a thermographic camera. Data on sites of maximum power deposition in phantoms will be used to determine optimum placement for invasive temperature monitoring probes during RF heating in living anesthetized animals. Heating patterns and rates of heating in animal phantoms and living anesthetized animals will be correlated with applicator configuration, tuning, spatial orientation of the sample, and incident and reflected power. The safety of using the device in living animals will be determined by careful monitoring of vital signs during RF application and short term observation of animals for surface or deep electrical burns outside the desired treatment area. If the above tasks are successfully accomplished, in years 2-4 the safety of heating specific sites in predetermined patterns to predetermined temperatures will be studied by observation of animals over 1 month and by serial laboratory tests, x-rays, and pathologic studies specific for each anatomic site heated. If these results are satisfactory an attempt will be made to gain experience in treatment of deep seated spontaneously arising tumors in domestic animals which are not considered candidates for conventional therapies. The long term goals of this project are to further develop devices and methodologies capable of applying deep precisely focused hyperthermia alone and in combination with radiotherapy and regional chemotherapy to tumors within the abdomen, thorax, pelvis, and central nervous system. At present, no totally satisfactory systems for precisely focused deep hyperthermia are available.

一种新的混合射频施加器，包括电感，电容， 以及相位和/或空间取向可变的接地元件 先前已经证明能够精确地集中加热， 均匀电介质体模中的深度为10 cm或以上。 这 器械将用于研究 在小型猪胴体中精确集中的深层加热 活体麻醉小型猪 将在解剖结构中尝试局部加热 腹部、骨盆、胸部和CNS中的部位选择，因为电流 在这些位置的肿瘤中应用热疗的困难。 最初，在小型猪尸体和复杂的 将监测处于热平衡的小型猪尸体的幻影 在加热过程中使用侵入式非场扰动探针。 随后，委员会注意到， 表面和各个平面上的二维加热模式 将使用热敏电阻测定通过横切体模 液晶纸和/或热成像照相机。 网站数据 将使用体模中的最大功率沉积来确定最佳 在射频加热期间放置侵入式温度监测探头， 活的麻醉动物 加热模式和加热速率 动物幻影和活的麻醉动物将与 施加器配置、调谐、样品的空间取向，以及 入射功率和反射功率。 将通过以下方式确定在活体动物中使用该器械的安全性 在射频应用期间和短期内仔细监测生命体征 观察动物体表或深部电烧伤， 理想的治疗区域。 如果上述任务顺利完成， 在第2-4年，以预定模式加热特定地点的安全性 将通过观察动物来研究 超过1个月，并通过一系列实验室检查、X线检查和病理学研究 针对每个加热的解剖部位。 如果这些结果令人满意 将尝试获得治疗深位 在家畜中自发产生的肿瘤， 常规治疗的候选人。 本项目的长期目标 进一步开发能够应用于深度的设备和方法， 单独精确聚焦热疗和联合放射治疗 以及对腹部、胸部、骨盆内的肿瘤进行区域化疗， 中枢神经系统 目前，还没有完全令人满意的系统， 精确聚焦的深度热疗是可用的。