IMMUNOGENETICS OF HYBRID RESISTANCE

混合抗性的免疫遗传学

• 批准号: 3174576
• 负责人: Michael Bennett
• 金额: $ 7.59万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-03-01 至 1987-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3174576
• 关键词: autoimmune disorder; bone marrow transplantation; cell fusion; clone cells; gene dosage; gene expression; genetic regulation; graft versus host disease; haploidy; heterozygote; histocompatibility antigens; immune tolerance /unresponsiveness; immunoglobulins; immunoregulation; major histocompatibility complex; monoclonal antibody; neoplasm /cancer immunology; newborn animals; radiation immunosuppression; structural genes

Hybrid resistance is the prevention of proliferation of grafts of H-2 homozygous normal or neoplastic hemopoietic cells by F1 hybrid mice heterozygous at H-2. This observation goes against the laws of transplantation genetics, which state that histocompatibility antigens are inherited codominantly. The determinants for the major hybrid or hemopoietic histocompatibility (Hh) antigens map at H-2D. The aims here are to determine if genes in the trans or cis configuration with Hh regulate expression so as to determine immunogenicity of donor cells and presence or absence of hybrid resistance in F1 hybrid hosts. The possibility of allogeneic inhibition, i.e., recognition of host alloantigens by the donor cells to initiate the response, will be investigated. Finally, the mechanism of tolerance induction to Hh antigens will be explored. The potential importance of this work relates to autoimmunity and tumor immune surveillance, since the parent and the F1 hybrid share the structural gene for the same Hh antigen. (SR)

杂交抗性是指阻止 H-2 移植物的增殖 F1 杂交小鼠的纯合正常或肿瘤性造血细胞 H-2 处杂合。 这一观察违反了法律 移植遗传学，指出组织相容性抗原 共显性遗传。 主要杂种的决定因素或 造血组织相容性 (Hh) 抗原图谱位于 H-2D。 这里的目标 确定带有 Hh 的基因是否处于反式或顺式构型 调节表达以确定供体细胞的免疫原性和 F1 杂交宿主中是否存在杂交抗性。 这 同种异体抑制的可能性，即识别宿主 由供体细胞产生的同种异体抗原来启动反应，将是 调查了。最后，Hh抗原耐受诱导机制 将被探索。 这项工作的潜在重要性涉及 自身免疫和肿瘤免疫监视，自亲本和 F1 杂交体共享相同 Hh 抗原的结构基因。 (SR)