DEVELOP NEW CLASS OF CHEMICAL RADIOSENSITIZATION

拟议研究的长期目标是开发一类新的 化学放射增敏剂。为了实现我们的总体目标，我们的 计划将包括： A.从不含的类别合成潜在的放射增敏剂 硝基，特别是异吲哚对苯二酮； B.测定这些化合物的物理化学性质； C.测定这些苯二酚的辐射化学性质 衍生品； D.在体内测定这些化合物的毒性和细胞毒性 和体外系统； E.测定异吲哚的辐射增敏潜力 使用EHS肉瘤和KHT肉瘤的体内系统中的醌类化合物 移植于小鼠体内； F.用不同的方法研究这些化合物的作用机理 放化疗联合治疗食道癌 癌变组织。 希望这些调查将为 开发一类新型化学放射增敏剂，它可能缺乏 一些当前测试的药物会出现不良副作用 感光剂。

The long range goal of the proposed research is to develop a new class of chemical radiosensitizers. In order to achieve our overall objective, our plan will be to: a. Synthesize potential radiosensitizers from a class that does not contain a nitro group, specifically isoindole quinones; b. determine physicochemical properties of these compounds; c. determine the radiation chemical characteristics of these quinone derivatives; d. determine the toxicity and cytotoxicity of these compounds using in vivo and in vitro systems; e. determine the radiosensitization potentialities of the isoindole quinones in an in vivo system using EHS sarcoma and KHT sarcoma transplanted in mice; f. investigate the mechanism of action of these compounds using different combined modalities in the radiation and chemical therapeutic treatment of cancerous tissues. It is hoped that these investigations will provide a basis for the development of a new class of chemical radiosensitizers, which may lack the undesired side effects encountered with some of the currently tested sensitizers.