NEUTRON ENERGY: DOSE PROTRACTION EFFECT ON TRANSFORMATI

个别细胞的肿瘤性转化被认为是 肿瘤发生的根本原因。电离辐射是一种强有力的诱导剂。 体外肿瘤转化的研究。最近的研究表明，两者都 投放的速度和辐射的质量会显著影响 观察到的转化频率。裂变光谱研究 阿贡国家实验室Janus反应堆的中子已经 结果表明，当温度较低时，诱导相变的能力大大增强。 剂量会随着时间的推移而延长。这些因素的影响 观察可能对那些职业或 在药物上暴露。 使用已适应于肿瘤检测的啮齿动物细胞 在体外转化时，我们建议确定以下几个方面：(1) 不同平均值肿瘤转化的剂量依赖关系 中子能量从0.86到25 MeV的平均能量；(2) 剂量延长(即低剂量率照射或多分次照射 高剂量率照射)作为FAST平均中子能量的函数 中子束；(3)增强诱发的机制 转化可以通过使用启动子和 抗促进剂(包括辐射防护剂)；和(4)可能的依据 抗启动剂对文职人员、医务人员的预防作用 可能暴露于长期暴露的患者和军事人员 来自不同平均能量来源的中子。

Neoplastic transformation of individual cells is believed to be the underlying cause of tumorigenesis. Ionizing radiation is a potent inducer of neoplastic transformation in vitro. Recent studies have shown that both the rate of delivery and the quality of the radiation can markedly affect the observed transformation frequency. Studies with fission-spectrum neutrons at the Janus reactor at the Argonne National Laboratory have indicated that induction of transformation is greatly enhanced when low doses are delivered protracted over time. The implications of these observations could be very important for those occupationally or medicinally exposed. Using rodent cells that have been adapted for the assay of neoplastic transformation in vitro, we propose to determine the following: (1) the dose dependency for neoplastic transformation for a variety of average neutron energies ranging from 0.86 to 25 MeV mean energy; (2) the effect of dose protraction (i.e., low-dose-rate irradiation or multifractionation of high-dose-rate exposures) as a function of average neutron energy of fast neutron beams; (3) the mechanism of the enhanced induction of transformation as can be studied through the use of promoters and antipromoters (including radioprotectors); and (4) the possible basis for the role of antipromoters as a prophylaxis for civilian personnel, medical patients, and military personnel who may be exposed to protracted exposures of neutrons from sources that have a variety of mean energies.