NMU INDUCED MAMMARY CANCER AND OMEGA 3 FATTY ACIDS
NMU 诱发乳腺癌和 Omega 3 脂肪酸
基本信息
- 批准号:3190884
- 负责人:
- 金额:$ 10.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1988
- 资助国家:美国
- 起止时间:1988-05-01 至 1991-04-30
- 项目状态:已结题
- 来源:
- 关键词:blood lipid breast neoplasms carcinogenesis inhibitor chemical carcinogenesis disease /disorder model hormone receptor laboratory rat lipid biosynthesis nitrosourea nutrition aspect of cancer nutrition related neoplasm /cancer nutrition related tag omega 3 fatty acid phosphatidylcholines phosphatidylethanolamines phosphatidylinositols phosphatidylserines phospholipids prolactin tumor promoters vegetable oils
项目摘要
The purpose of this study is to determine the role played by
omega-3 fatty acids in mammary carcinogenesis. The N-
nitrosomethylurea-(MNU)- induced rat mammary tumor will serve
as a model for human breast cancer. The experimental diets are
designed such that the ratio of omega-6/omega-3 fatty acids will
vary form 7:1 to 2:1 and 0.7:1. (The ratio in the contemporary
Western diet is approximately 10:1). The experimental diets will
be fed at 23% (wt/wt), which approximates the current U.S. fat
intake. High-fat (HF) and low-fat (LF) corn oil (23% and 5%,
respectively) will serve as internal controls. If the balance of
omega-6/omega-3 fatty acids plays a determining role in
mammary tumor development, then tumor incidence should
approach that of the LF corn oil group as omega-3 levels increase;
if, on the other hand omega-3 fatty acids have effects similar to
omega-6 fatty acids, then tumor incidences should remain in the
HF corn oil range.
The experimental protocols are designed to test the effects of
omega-3 fatty acids on (a) the initiation phase, (b) the promotion
phase, and (c) both the initiation and promotion phases. In this
way, the stage in carcinogenesis at which the optimal
chemopreventive effects of omega-3 fatty acids are exerted can
be determined. Such information is important, both theoretically
and in the design of dietary intervention trials. Evidence suggest
that omega-3 fatty acids compete with omega-6 fatty acids for
common metabolic pathways. As a result omega-3 fatty acids
may replace omega-6 fatty acids in cell membranes, thereby
altering the structural and functional integrity of the membrane.
Since diet has been shown to alter serum prolactin levels and
prolactin receptor status, we propose to test the hypothesis that
the tumor-inhibiting effects of omega-3 diets may be exerted via
changes in membrane-bound prolactin receptors and/or changes in
circulating levels of prolactin, a known tumor promoter. To test
this hypothesis, the fatty acid composition of (a) serum neutral
and phospholipids and (b) tumor neutral lipids and the four new
major subclasses of phospholipids, namely, phosphatidyl choline,
phosphatidyl inositol, phosphatidyl serine and phosphatidyl
ethanolamine will be determined. In addition, both
immunoassayable and bioassayable serum prolactin and tumor
prolactin receptor content will be assessed in each treatment
group.
The ultimate objective of this proposal is the development of an
optimal omega-6/omega-3 dietary fatty acid balance for the
primary and secondary prevention of breast cancer in high-risk
countries, such as the U.S.A.
本研究的目的是确定所扮演的角色
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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LEONARD A COHEN其他文献
LEONARD A COHEN的其他文献
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{{ truncateString('LEONARD A COHEN', 18)}}的其他基金
Patient Visits to Physician Offices and/or Emergency Rooms for Dental Problems
因牙科问题前往医生办公室和/或急诊室就诊的患者
- 批准号:
7129125 - 财政年份:2006
- 资助金额:
$ 10.01万 - 项目类别:
Patient Visits to Physician Offices and/or Emergency Rooms for Dental Problems
因牙科问题前往医生办公室和/或急诊室就诊的患者
- 批准号:
7243474 - 财政年份:2006
- 资助金额:
$ 10.01万 - 项目类别:
Toothache Pain: Sources of Care and Self-Remedies
牙痛:护理和自我治疗的来源
- 批准号:
6885566 - 财政年份:2004
- 资助金额:
$ 10.01万 - 项目类别:
Toothache Pain: Sources of Care and Self-Remedies
牙痛:护理和自我治疗的来源
- 批准号:
6948278 - 财政年份:2004
- 资助金额:
$ 10.01万 - 项目类别:
ADULT MEDICAID PATIENTS' DENTAL VISITS IN EDS
EDS 中成人医疗补助患者的牙科就诊
- 批准号:
2885650 - 财政年份:1999
- 资助金额:
$ 10.01万 - 项目类别:
ENZYME THERAPY AND EXPERIMENTAL MAMMARY METASTASIS
酶疗法和实验性乳腺转移
- 批准号:
2284866 - 财政年份:1994
- 资助金额:
$ 10.01万 - 项目类别:
VOLUNTARY EXERCISE AS MEANS OF MAMMARY CANCER PREVENTION
自愿锻炼作为预防乳腺癌的手段
- 批准号:
3192680 - 财政年份:1988
- 资助金额:
$ 10.01万 - 项目类别:
VOLUNTARY EXERCISE AS MEANS OF MAMMARY CANCER PREVENTION
自愿锻炼作为预防乳腺癌的手段
- 批准号:
3192679 - 财政年份:1988
- 资助金额:
$ 10.01万 - 项目类别:
VOLUNTARY EXERCISE AS MEANS OF MAMMARY CANCER PREVENTION
自愿锻炼作为预防乳腺癌的手段
- 批准号:
3192677 - 财政年份:1988
- 资助金额:
$ 10.01万 - 项目类别:
NMU INDUCED MAMMARY CANCER AND OMEGA 3 FATTY ACIDS
NMU 诱发乳腺癌和 Omega 3 脂肪酸
- 批准号:
3190883 - 财政年份:1988
- 资助金额:
$ 10.01万 - 项目类别:
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