NMU INDUCED MAMMARY CANCER AND OMEGA 3 FATTY ACIDS

NMU 诱发乳腺癌和 Omega 3 脂肪酸

基本信息

  • 批准号:
    3190884
  • 负责人:
  • 金额:
    $ 10.01万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1988
  • 资助国家:
    美国
  • 起止时间:
    1988-05-01 至 1991-04-30
  • 项目状态:
    已结题

项目摘要

The purpose of this study is to determine the role played by omega-3 fatty acids in mammary carcinogenesis. The N- nitrosomethylurea-(MNU)- induced rat mammary tumor will serve as a model for human breast cancer. The experimental diets are designed such that the ratio of omega-6/omega-3 fatty acids will vary form 7:1 to 2:1 and 0.7:1. (The ratio in the contemporary Western diet is approximately 10:1). The experimental diets will be fed at 23% (wt/wt), which approximates the current U.S. fat intake. High-fat (HF) and low-fat (LF) corn oil (23% and 5%, respectively) will serve as internal controls. If the balance of omega-6/omega-3 fatty acids plays a determining role in mammary tumor development, then tumor incidence should approach that of the LF corn oil group as omega-3 levels increase; if, on the other hand omega-3 fatty acids have effects similar to omega-6 fatty acids, then tumor incidences should remain in the HF corn oil range. The experimental protocols are designed to test the effects of omega-3 fatty acids on (a) the initiation phase, (b) the promotion phase, and (c) both the initiation and promotion phases. In this way, the stage in carcinogenesis at which the optimal chemopreventive effects of omega-3 fatty acids are exerted can be determined. Such information is important, both theoretically and in the design of dietary intervention trials. Evidence suggest that omega-3 fatty acids compete with omega-6 fatty acids for common metabolic pathways. As a result omega-3 fatty acids may replace omega-6 fatty acids in cell membranes, thereby altering the structural and functional integrity of the membrane. Since diet has been shown to alter serum prolactin levels and prolactin receptor status, we propose to test the hypothesis that the tumor-inhibiting effects of omega-3 diets may be exerted via changes in membrane-bound prolactin receptors and/or changes in circulating levels of prolactin, a known tumor promoter. To test this hypothesis, the fatty acid composition of (a) serum neutral and phospholipids and (b) tumor neutral lipids and the four new major subclasses of phospholipids, namely, phosphatidyl choline, phosphatidyl inositol, phosphatidyl serine and phosphatidyl ethanolamine will be determined. In addition, both immunoassayable and bioassayable serum prolactin and tumor prolactin receptor content will be assessed in each treatment group. The ultimate objective of this proposal is the development of an optimal omega-6/omega-3 dietary fatty acid balance for the primary and secondary prevention of breast cancer in high-risk countries, such as the U.S.A.
本研究的目的是确定所扮演的角色

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

LEONARD A COHEN其他文献

LEONARD A COHEN的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('LEONARD A COHEN', 18)}}的其他基金

Patient Visits to Physician Offices and/or Emergency Rooms for Dental Problems
因牙科问题前往医生办公室和/或急诊室就诊的患者
  • 批准号:
    7129125
  • 财政年份:
    2006
  • 资助金额:
    $ 10.01万
  • 项目类别:
Patient Visits to Physician Offices and/or Emergency Rooms for Dental Problems
因牙科问题前往医生办公室和/或急诊室就诊的患者
  • 批准号:
    7243474
  • 财政年份:
    2006
  • 资助金额:
    $ 10.01万
  • 项目类别:
Toothache Pain: Sources of Care and Self-Remedies
牙痛:护理和自我治疗的来源
  • 批准号:
    6885566
  • 财政年份:
    2004
  • 资助金额:
    $ 10.01万
  • 项目类别:
Toothache Pain: Sources of Care and Self-Remedies
牙痛:护理和自我治疗的来源
  • 批准号:
    6948278
  • 财政年份:
    2004
  • 资助金额:
    $ 10.01万
  • 项目类别:
ADULT MEDICAID PATIENTS' DENTAL VISITS IN EDS
EDS 中成人医疗补助患者的牙科就诊
  • 批准号:
    2885650
  • 财政年份:
    1999
  • 资助金额:
    $ 10.01万
  • 项目类别:
ENZYME THERAPY AND EXPERIMENTAL MAMMARY METASTASIS
酶疗法和实验性乳腺转移
  • 批准号:
    2284866
  • 财政年份:
    1994
  • 资助金额:
    $ 10.01万
  • 项目类别:
VOLUNTARY EXERCISE AS MEANS OF MAMMARY CANCER PREVENTION
自愿锻炼作为预防乳腺癌的手段
  • 批准号:
    3192680
  • 财政年份:
    1988
  • 资助金额:
    $ 10.01万
  • 项目类别:
VOLUNTARY EXERCISE AS MEANS OF MAMMARY CANCER PREVENTION
自愿锻炼作为预防乳腺癌的手段
  • 批准号:
    3192679
  • 财政年份:
    1988
  • 资助金额:
    $ 10.01万
  • 项目类别:
VOLUNTARY EXERCISE AS MEANS OF MAMMARY CANCER PREVENTION
自愿锻炼作为预防乳腺癌的手段
  • 批准号:
    3192677
  • 财政年份:
    1988
  • 资助金额:
    $ 10.01万
  • 项目类别:
NMU INDUCED MAMMARY CANCER AND OMEGA 3 FATTY ACIDS
NMU 诱发乳腺癌和 Omega 3 脂肪酸
  • 批准号:
    3190883
  • 财政年份:
    1988
  • 资助金额:
    $ 10.01万
  • 项目类别:

相似海外基金

Pathology of Breast Neoplasms determined by MRS
MRS 测定乳腺肿瘤的病理学
  • 批准号:
    nhmrc : 950215
  • 财政年份:
    1995
  • 资助金额:
    $ 10.01万
  • 项目类别:
    NHMRC Project Grants
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了