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DIET AND BREAST TISSUE MORPHOLOGY ON MAMMOGRAMS

乳房 X 线照片上的饮食和乳腺组织形态

基本信息

批准号：
3191586
负责人：
LOIS A MONTEIRO
金额：
$ 22.3万
依托单位：
BROWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1988
资助国家：
美国
起止时间：
1988-09-30 至 1993-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3191586
关键词：
all trans retinol cancer prevention cancer risk carotenoids dietary fiber dietary lipid human middle age (35-64) human subject mammography nutrition aspect of cancer nutrition related tag retinoids saturated fat tocopherols

项目摘要

The long-term goal of this study is the development of preventive measures for cancer of breast. The principal specific aims are to relate mammographic features of breast tissue to the dietary intakes of total fat, saturated fat, carotenoids and fiber, and to serum levels of beta-carotene, other carotenoids, retinol and vitamin E. The study will be based on women attending a state-wide screening program for breast cancer in Rhode Island. A total of 2000 women will be identified who are 40-59 years old at screening, who do not report symptoms of breast disease, and who do not have mammographic findings that are suspicious of cancer. Subjects will be interviewed at home with respect to dietary history and other known or suspected risk factors for breast cancer. The dietary history will use the food frequency method supplemented with food models to help estimate portion size. The data will be used to estimate intake of fats, carotenoids, fiber and other nutrients in the year preceding the interview. Subjects will also be asked for a blood specimen. These will be analyzed by high-performance liquid chromatography for retinol, fractionated carotenoids, and alpha- and gamma-tocopherol. Mammograms will be evaluated by a single reviewer without reference to other data on subjects. Features to be evaluated include Wolfe's parenchymal pattern, the radiologic components of the parenchymal pattern, and the breast size. Relations between dietary intakes, serum measurements and mammographic characteristics will be analyzed by use of tabular and regression methods.

本研究的长期目标是开发预防性药物乳腺癌的治疗方法主要的具体目标是将乳房组织的乳房X线摄影特征与饮食总脂肪、饱和脂肪、类胡萝卜素和纤维的摄入量，血清β-胡萝卜素、其他类胡萝卜素、视黄醇和维生素E. 这项研究将基于参加全州范围内的妇女罗得岛的乳腺癌筛查项目。共筛选时将确定2000名40-59岁的女性，没有报告乳腺疾病症状，乳房X光检查结果疑似癌症。受试者将在家里接受关于饮食史和其他已知或疑似乳腺癌的危险因素。膳食历史将使用食物频率法辅以食物模型，以帮助估计部分大小。这些数据将被用来估计脂肪、类胡萝卜素、纤维和其他营养素的摄入量，面试前一年。受试者还将被要求血液样本这些将由高性能用于视黄醇、分级分离的类胡萝卜素和 α-和γ-生育酚。乳房X线检查将由不参考受试者的其他数据。待评估的特征包括Wolfe实质模式，实质模式和乳房的放射学成分尺寸膳食摄入量、血清测量值和将使用表格和回归方法