TOTAL SYNTHESIS OF ANTICANCER AGENTS

抗癌剂的全合成

• 批准号: 3189719
• 负责人: K. C. NICOLAOU
• 金额: $ 20.87万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-01 至 1994-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3189719
• 关键词: DNA; analog; antineoplastic antibiotics; biological products; chemical cleavage; chemical models; chemical reaction; drug design /synthesis /production; epoxides; glycosides; heterocyclic polycyclic compound; neoplasm /cancer chemotherapy; nitrogenous heterocyclic compound; protective chemical group; quinones; stereochemistry

This program is directed towards the development of new synthetic technology and strategies relating to the enediyne anticancer agents calicheamicin gamma1 l and dynemicin A. The developed methodology will be applied to the total synthesis of the natural products themselves and to the design, synthesis and biological evaluation of a number of related model compounds. It is anticipated that the proposed work will have significance in the areas of organic synthesis, biomedical research, and cancer chemotherapy.

该程序致力于开发新的合成 与Enediyne抗癌代理有关的技术和策略 Calicheamicin gamma1 L和DynemicinA。开发的方法将 适用于天然产品本身的总合成 多个设计，合成和生物学评估 相关模型化合物。 预计拟议的工作将 在有机合成，生物医学领域具有重要意义 研究和癌症化疗。