DOSE COMPARISON OF STEREOTACTIC RADIOSURGICAL MODALITIES

立体定向放射外科手术方式的剂量比较

• 批准号: 3195713
• 负责人: Mark H. Phillips
• 金额: $ 0.32万
• 依托单位: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-01 至 1991-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3195713
• 关键词: combination cancer therapy; disease /disorder model; head /neck neoplasm; neoplasm /cancer radiation therapy; neoplasm /cancer surgery; particle accelerators; proton beam; radiation therapy dosage; skull; stereotaxic techniques

Different techniques of small field stereotaxic external beam radiotherapy, also known as stereotactic radiosurgery, or intracranial lesions will be compared by means of dose distributions calculated using a CT-based, 3- dimensional treatment planning computer program. Radiosurgical treatment of intracranial tumors and vascular malformations has proven to be a very successful means of curing life-threatening and debilitating lesions in thousands of patients. These results have been achieved by a small number of radiosurgical modalities with specific treatment protocols. Recently, a number of new radiosurgical modalities have been implemented or proposed, and the use of these techniques is spreading rapidly. In order to evaluate different radiosurgical modalities, a systematic comparison of dose distributions will be performed, and the results evaluated by means of dose-volume histograms. Radiation types that will be studied are charged particles (protons, helium ions, carbon ions, and neon ions) and photons (Co 60 gamma-rays and megavoltage photons from linear accelerators). Irradiation geometries (the number, orientation, and weighting of beamports) that will be studied are the currently-used charged particle methods at Lawrence Berkeley Laboratory (LBL) and the Harvard Cyclotron, the Co 60 Gamma Knife, and a number of Linac-based rotational arc methods, including the methods used in Heidelberg, Boston, and Montreal. The dose to the target volume and to regions of normal tissue will be compared. The effects of the target size, shape, and location on the patterns of dose distribution will be studied in order to determine classes of lesions best treated by particular radiosurgical methods. Use will be made of clinical data at LBL in order to help determine dose-volume relationships of clinical effects.

小视野立体定向外束放射治疗的不同技术， 也称为立体定向放射外科手术，或将颅内病变 通过使用基于 CT 的 3- 计算剂量分布进行比较 三维治疗计划计算机程序。 放射外科治疗 颅内肿瘤和血管畸形已被证明是一个非常 治愈危及生命和使人衰弱的病变的成功方法 数千名患者。 这些成果是由少数人取得的 具有特定治疗方案的放射外科模式。 最近，一个 已经实施或提议了许多新的放射外科方法， 这些技术的使用正在迅速普及。 为了评估 不同放射外科方式，剂量的系统比较 将进行分配，并通过以下方式评估结果 剂量-体积直方图。 将要研究的辐射类型是收费的 粒子（质子、氦离子、碳离子和氖离子）和光子 （Co 60 伽马射线和来自线性加速器的兆伏光子）。 辐射几何形状（辐射的数量、方向和权重） 将研究的波束端口是当前使用的带电粒子 劳伦斯伯克利实验室 (LBL) 和哈佛回旋加速器的方法， Co 60 伽玛刀和许多基于直线加速器的旋转弧方法， 包括海德堡、波士顿和蒙特利尔使用的方法。 剂量 将与目标体积和正常组织区域进行比较。 这 目标尺寸、形状和位置对剂量模式的影响 将研究分布以确定最佳病变类别 通过特殊的放射外科方法进行治疗。 将利用临床 LBL 数据，以帮助确定剂量-体积关系 临床效果。