BEHAVIORAL PHARMACOLOGY OF CHRONIC BENZODIAZEPINE USE

长期使用苯二氮卓类药物的行为药理学

• 批准号: 3211482
• 负责人: MARY JEANNE KALLMAN
• 金额: $ 7.44万
• 依托单位: UNIVERSITY OF MISSISSIPPI
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-04-01 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3211482
• 关键词: behavior test; behavioral medicine; benzodiazepines; diazepam; dosage; drug abuse; drug tolerance; drug withdrawal; laboratory rat; operant conditionings; pharmacokinetics; psychological reinforcement; psychopharmacology; tranquilizer

The proposed experiments will compare the importance of behavioral conditioning factors in the development of tolerance to two anxiolytic drugs, diazepam and midazolam. Tolerance to the sedative effects of these compounds is an integral factor in the abuse and clinical use of sedatives. Widely available midazolam and diazepam have been selected for comparison because of the known difference in duration of action which has been implicated in both processes of drug tolerance and withdrawal. Dose of drug administered will be examined as an important variable in the relationship between conditioning factors and tolerance to midazolam. Special emphasis will be placed on the process of how conditioning factors affect tolerance development and withdrawal characteristics rather than merely observing the existence of conditioning factors. A comprehensive description of behavioral tolerance to these anxiolytics will be accomplished by evaluating response rates, duration of responses, interresponse times, and the force of the responses under various schedules of operant performance. Further delineation of tolerance and withdrawal processes which are important in the repetitive use of these drugs will have implications for the treatment of abusers and in the use of these compounds to treat opiate, cocaine and alcohol abuse.

拟议的实验将比较的重要性， 耐受性形成中的行为条件因素 安定和咪达唑仑这两种抗焦虑药。 耐 这些化合物的镇静作用是 滥用和临床使用镇静剂。 广泛提供 选择咪达唑仑和地西泮进行比较， 已知的作用持续时间的差异， 与药物耐受和戒断过程有关。 给药剂量将作为重要的 调节因素之间关系的变量， 对咪达唑仑的耐受性 将特别强调 调节因素如何影响耐受性发展的过程 而不仅仅是观察 条件因素的存在。 的全面描述 对这些抗焦虑药物的行为耐受性将得以实现 通过评估响应率，响应持续时间， 响应时间，以及各种条件下的响应力 操作性能的时间表。 进一步划定 容忍和撤退过程，这是重要的， 重复使用这些药物将对 滥用者的治疗以及这些化合物用于治疗 鸦片、可卡因和酗酒。