CYCLOSPROINE AND LIVER CARCINOGENESIS

环脯氨酸与肝癌发生

基本信息

项目摘要

The major objective of the proposed study is to clarify the mechanisms underlying the control of tumor growth and progression, using the experimental models of liver carcinogenesis and an immunosuppressant, cyclosporine (CsA). CsA is presently one of the most successful immunosuppressants used in clinical organ transplantation, but its use is associated with the development of various malignancies. Further, the efficacy of CsA on liver transplants of patients with primary liver tumors is questionable because of a high rate of recurrence of tumors in recipient liver. Our preliminary data indicated that an immunosuppressive dose of CsA had profound effects on tumor progression in murine epidermal carcinogenesis and on the growth of preneoplastic lesions in the liver. Both the skin and the liver contain immunologically relevant cells, Thy 1+ epidermal dendritic cells and liver associated large granular lymphocytes (Pit cells ) , but their functions are not fully characterized. Possible involvement of liver non parenchymal cells in control of normal and malignant cell growth has been reported. We postulate that one of the underlying mechanisms of CsA-modulation of tumor growth is mediated through altered functions of the organ associated immunoregulatory cells. In the proposal, we will clarify further biological roles of CsA on the process of tumor progression in liver carcinogenesis. Effects of CsA on liver parenchymal cell proliferation and on liver non parenchymal cell functions including the cytotoxicity of pit cells will be investigated. In addition, possible involvement of liver non parenchymal cells including pit cells in the control of liver cell growth via paracrine regulations of growth factors (i.e. transforming growth factor beta) will be explored. These studies will provide a new insight into the roles of organ associated immunoregulatory cells on the selective growth of preneoplastic cells and on the process of tumor progression.
本研究的主要目的是阐明其机制

项目成果

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HISASHI SHINOZUKA其他文献

HISASHI SHINOZUKA的其他文献

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{{ truncateString('HISASHI SHINOZUKA', 18)}}的其他基金

CYCLOSPROINE AND LIVER CARCINOGENESIS
环脯氨酸与肝癌发生
  • 批准号:
    3198158
  • 财政年份:
    1991
  • 资助金额:
    $ 16.32万
  • 项目类别:
CYCLOSPORINE AND LIVER CARCINOGENESIS
环孢菌素与肝癌发生
  • 批准号:
    2095330
  • 财政年份:
    1991
  • 资助金额:
    $ 16.32万
  • 项目类别:
CYCLOSPORINE AND LIVER CARCINOGENESIS
环孢菌素与肝癌发生
  • 批准号:
    2095331
  • 财政年份:
    1991
  • 资助金额:
    $ 16.32万
  • 项目类别:
CYCLOSPROINE AND LIVER CARCINOGENESIS
环脯氨酸与肝癌发生
  • 批准号:
    3198157
  • 财政年份:
    1991
  • 资助金额:
    $ 16.32万
  • 项目类别:
LIVER CANCERS BY HYPOLIPIDEMIC PEROXISOME PROLIFERATORS
低血脂过氧化物酶体增殖剂引起的肝癌
  • 批准号:
    3179507
  • 财政年份:
    1985
  • 资助金额:
    $ 16.32万
  • 项目类别:
LIVER CANCERS BY HYPOLIPIDEMIC PEROXISOME PROLIFERATORS
低血脂过氧化物酶体增殖剂引起的肝癌
  • 批准号:
    3179509
  • 财政年份:
    1985
  • 资助金额:
    $ 16.32万
  • 项目类别:
LIVER CANCERS BY HYPOLIPIDEMIC PEROXISOME PROLIFERATORS
低血脂过氧化物酶体增殖剂引起的肝癌
  • 批准号:
    3179508
  • 财政年份:
    1985
  • 资助金额:
    $ 16.32万
  • 项目类别:
CYCLOSPORIN A, POSSIBLE PROMOTOR OF LYMPHOMA INDUCTION
环孢菌素 A,淋巴瘤诱导的可能促进剂
  • 批准号:
    3173678
  • 财政年份:
    1984
  • 资助金额:
    $ 16.32万
  • 项目类别:
CYCLOSPORINE A: PROMOTER OF LYMPHOMA INDUCTION
环孢菌素 A:淋巴瘤诱导的促进剂
  • 批准号:
    3173680
  • 财政年份:
    1984
  • 资助金额:
    $ 16.32万
  • 项目类别:
CYCLOSPORIN A, POSSIBLE PROMOTOR OF LYMPHOMA INDUCTION
环孢菌素 A,淋巴瘤诱导的可能促进剂
  • 批准号:
    3173677
  • 财政年份:
    1984
  • 资助金额:
    $ 16.32万
  • 项目类别:

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分子和细胞肿瘤学研究计划
  • 批准号:
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  • 财政年份:
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    6295933
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    1999
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Molecular and cellular oncology program
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  • 批准号:
    6217380
  • 财政年份:
    1999
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    $ 16.32万
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Molecular and Cellular Oncology Program
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  • 批准号:
    10599102
  • 财政年份:
    1997
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Molecular and Cellular Oncology Program
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  • 批准号:
    10332912
  • 财政年份:
    1997
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    $ 16.32万
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  • 财政年份:
    1988
  • 资助金额:
    $ 16.32万
  • 项目类别:
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