CYCLOSPROINE AND LIVER CARCINOGENESIS
环脯氨酸与肝癌发生
基本信息
- 批准号:3198156
- 负责人:
- 金额:$ 16.32万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1991
- 资助国家:美国
- 起止时间:1991-01-01 至 1995-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The major objective of the proposed study is to clarify the mechanisms
underlying the control of tumor growth and progression, using the
experimental models of liver carcinogenesis and an immunosuppressant,
cyclosporine (CsA). CsA is presently one of the most successful
immunosuppressants used in clinical organ transplantation, but its use is
associated with the development of various malignancies. Further, the
efficacy of CsA on liver transplants of patients with primary liver tumors
is questionable because of a high rate of recurrence of tumors in recipient
liver. Our preliminary data indicated that an immunosuppressive dose of CsA
had profound effects on tumor progression in murine epidermal
carcinogenesis and on the growth of preneoplastic lesions in the liver.
Both the skin and the liver contain immunologically relevant cells, Thy 1+
epidermal dendritic cells and liver associated large granular lymphocytes
(Pit cells ) , but their functions are not fully characterized. Possible
involvement of liver non parenchymal cells in control of normal and
malignant cell growth has been reported. We postulate that one of the
underlying mechanisms of CsA-modulation of tumor growth is mediated through
altered functions of the organ associated immunoregulatory cells. In the
proposal, we will clarify further biological roles of CsA on the process
of tumor progression in liver carcinogenesis. Effects of CsA on liver
parenchymal cell proliferation and on liver non parenchymal cell functions
including the cytotoxicity of pit cells will be investigated. In addition,
possible involvement of liver non parenchymal cells including pit cells in
the control of liver cell growth via paracrine regulations of growth
factors (i.e. transforming growth factor beta) will be explored. These
studies will provide a new insight into the roles of organ associated
immunoregulatory cells on the selective growth of preneoplastic cells and
on the process of tumor progression.
本研究的主要目的是阐明其机制
项目成果
期刊论文数量(0)
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HISASHI SHINOZUKA其他文献
HISASHI SHINOZUKA的其他文献
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{{ truncateString('HISASHI SHINOZUKA', 18)}}的其他基金
LIVER CANCERS BY HYPOLIPIDEMIC PEROXISOME PROLIFERATORS
低血脂过氧化物酶体增殖剂引起的肝癌
- 批准号:
3179507 - 财政年份:1985
- 资助金额:
$ 16.32万 - 项目类别:
LIVER CANCERS BY HYPOLIPIDEMIC PEROXISOME PROLIFERATORS
低血脂过氧化物酶体增殖剂引起的肝癌
- 批准号:
3179509 - 财政年份:1985
- 资助金额:
$ 16.32万 - 项目类别:
LIVER CANCERS BY HYPOLIPIDEMIC PEROXISOME PROLIFERATORS
低血脂过氧化物酶体增殖剂引起的肝癌
- 批准号:
3179508 - 财政年份:1985
- 资助金额:
$ 16.32万 - 项目类别:
CYCLOSPORIN A, POSSIBLE PROMOTOR OF LYMPHOMA INDUCTION
环孢菌素 A,淋巴瘤诱导的可能促进剂
- 批准号:
3173678 - 财政年份:1984
- 资助金额:
$ 16.32万 - 项目类别:
CYCLOSPORINE A: PROMOTER OF LYMPHOMA INDUCTION
环孢菌素 A:淋巴瘤诱导的促进剂
- 批准号:
3173680 - 财政年份:1984
- 资助金额:
$ 16.32万 - 项目类别:
CYCLOSPORIN A, POSSIBLE PROMOTOR OF LYMPHOMA INDUCTION
环孢菌素 A,淋巴瘤诱导的可能促进剂
- 批准号:
3173677 - 财政年份:1984
- 资助金额:
$ 16.32万 - 项目类别:
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- 资助金额:
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