RESISTANCE TO CHEMICALLY INDUCED LYMPHOMA IN MICE
小鼠对化学诱导淋巴瘤的抵抗力
基本信息
- 批准号:3197416
- 负责人:
- 金额:$ 25.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1990
- 资助国家:美国
- 起止时间:1990-07-01 至 1995-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Very little is known about human genes that can confer increased
susceptibility or resistance to environmental carcinogens. Most exciting
knowledge has been obtained from studies based on the much extensive
experimental data obtained in laboratory animals. The studies proposed
here are aimed at elucidating the genetic basis of the marked differences
in the incidence of T-cell lymphoma among mice of certain inbred strains
following percutaneous application of 3-methylcholanthrene (MA). The
primary goal is to build upon our previous data indicating that a single
dominant gene is the major determinant of relative resistance to MA
lymphomagenesis and to map this gene. The goal will be studied first in an
analysis of DNA from mice of a new set of recombinant inbred (RI) mice,
SWXD1, by searching for correlations between MA lymphoma incidence and
other genetic polymorphisms, primarily restriction fragment length
polymorphisms detected by the use of probes for endogenous murine leukemia
viruses, that are widely distributed among the chromosomes of mice.
Similarly, this same approach will be applied to the analysis of DNAs from
individual mice of a large backcross population segregating for the
presence or absence of the MA resistance gene and observed for lymphoma
after MA treatment. Another goal stems from experiments suggesting that
this same resistance gene may play a role in resistance to lymphomagenesis
by fractionated doses of whole body irradiation; this possibility will also
be studied in the SWXD1 strains by comparing the lymphoma incidences in
each strain after treatment with MCA vs. irradiation. A third goal
involves the exploration of the genetic basis for the marked, genetically
recessive hypersensitivity of mice of the RF/J strain to lymphomagenesis by
a low total dose (200 rad) of fractionated irradiation, by comparison with
other strains that are highly susceptible at higher doses but resistant at
the low dose. We will pursue any suggestions of biological mechanisms that
might be responsible for these differences in lymphoma resistance by
attempting to correlate them with the distributions of the resistance
genes.
我们对人类基因是否能增加体重知之甚少
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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FRANK LILLY其他文献
FRANK LILLY的其他文献
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{{ truncateString('FRANK LILLY', 18)}}的其他基金
MECHANISMS OF THE H-2 EFFECT ON VIRAL LEUKEMOGENESIS
H-2 对病毒性白血病发生的影响机制
- 批准号:
3165211 - 财政年份:1991
- 资助金额:
$ 25.01万 - 项目类别:
MECHANISM OF THE H-2 EFFECT OF VIRAL LEUKEMOGENESIS
病毒性白血病的 H-2 效应机制
- 批准号:
3165218 - 财政年份:1991
- 资助金额:
$ 25.01万 - 项目类别:
MECHANISMS OF THE H-2 EFFECT ON VIRAL LEUKEMOGENESIS
H-2 对病毒性白血病发生的影响机制
- 批准号:
3165217 - 财政年份:1991
- 资助金额:
$ 25.01万 - 项目类别:
MECHANISM OF THE H-2 EFFECT OF VIRAL LEUKEMOGENESIS
病毒性白血病的 H-2 效应机制
- 批准号:
2086793 - 财政年份:1991
- 资助金额:
$ 25.01万 - 项目类别:
RESISTANCE TO CHEMICALLY INDUCED LYMPHOMA IN MICE
小鼠对化学诱导淋巴瘤的抵抗力
- 批准号:
3197415 - 财政年份:1990
- 资助金额:
$ 25.01万 - 项目类别:
RESISTANCE TO CHEMICALLY INDUCED LYMPHOMA IN MICE
小鼠对化学诱导淋巴瘤的抵抗力
- 批准号:
3197417 - 财政年份:1990
- 资助金额:
$ 25.01万 - 项目类别:
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