BIRTH CHARACTERISTICS AND BREAST CANCER RISK

出生特征和乳腺癌风险

• 批准号: 3204396
• 负责人: DIMITRIOS V TRICHOPOULOS
• 金额: $ 10.3万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-01 至 1995-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3204396
• 关键词: biomarker; breast neoplasms; cancer risk; estrogens; female; human birth weight; human pregnant subject; preeclampsia; pregnancy; pregnancy toxemia /hypertension; prenatal stress; statistics /biometry

DESCRIPTION: (Adapted from Investigator's Abstract) It has been hypothesized that intrauterine exposure to increased levels of endogenous pregnancy estrogens may play an important role in the etiology of breast cancer. There are several likely indicators of levels of pregnancy estrogens but for two of them the evidence is overwhelming and the respective relations strong: pregnancy toxemia (preeclampsia/eclampsia) is associated with low levels of pregnancy estrogens; and there is a positive correlation between pregnancy estrogens and measures of fetal size. The investigators propose to examine the relation between these indicators and subsequent breast cancer occurrence in a nested case-control study in Sweden. The base population consists of more than 150,000 women who were delivered at the Uppsala University Hospital from 1874 to 1954 and at the county hospitals of Sundsvall, Falun, and Eskilstuno from 1920 to 1857. Incident cases of breast cancer among these women will be identified through their unique national registration number in the Swedish cancer Registry during 1958-1990. For each case the females born to the first three mothers admitted after the case's mother will be selected as potential matching controls. Only controls living in Sweden and free from breast cancer until the time of diagnosis of breast cancer in the corresponding case will be included in the analysis. Tracing of eligible controls is done through successive parish data, the Swedish Death Registry, and the Swedish Cancer Registry. It is estimated that approximately 1,100 breast cancer cases and 3,100 age and birth-date matched controls will be included in the study. Standard analytic methods with conditional logistic regression for matched case-control studies will be carried out.Maternal length and placental weight will be examined as the risk determinants. In addition, maternal preeclampsia and eclampsia during the previous pregnancies will be analyzed to address whether features during the pregnancy or constitutional characteristics of the mother are the more important determinants.

描述：（改编自研究者摘要） 假设子宫内暴露于高水平的 内源性妊娠雌激素可能在 乳腺癌的病因。 有几个可能的迹象表明， 怀孕雌激素水平，但其中两个证据是， 压倒性和各自的关系强：妊娠毒血症 （先兆子痫/子痫）与低水平的妊娠有关 雌激素;怀孕和怀孕之间存在正相关性 雌激素和胎儿大小的测量。 研究人员建议 检查这些指标与随后的乳腺癌之间的关系 在瑞典进行的一项巢式病例对照研究中， 基座 人口由15万多名在医院分娩的妇女组成， 乌普萨拉大学医院，1874年至1954年， 松兹瓦尔、法轮和埃斯基尔斯图诺的医院，1920年至1857年。 将查明这些妇女中的乳腺癌病例 通过他们在瑞典癌症中唯一的国家注册号， 1958-1990年期间的书记官处。 在每一种情况下， 三位母亲入院后，将被选中的母亲作为病例 潜在的匹配控制。 只控制生活在瑞典和自由 从乳腺癌到乳腺癌的诊断时间， 相应病例将纳入分析。 追踪符合条件的 控制是通过连续的教区数据，瑞典死亡 瑞典癌症登记处（Swedish Cancer Registry） 据估计 大约1，100例乳腺癌病例和3，100例年龄和出生日期 匹配的对照将包括在研究中。 标准分析 配对病例对照的条件Logistic回归方法 将进行研究。母体长度和胎盘重量将 作为风险的决定因素。 此外，产妇 先兆子痫和子痫在以前的怀孕将是 分析以解决怀孕期间的特征或 母亲的体质特征更重要 决定因素